Synthesis and blood compatibilities of novel segmented polyurethanes grafted phospholipid analogous vinyl monomers and polyfunctional monomers

A. Korematsu, T. Tomita, S. Kuriyama, T. Hanada, S. Sakamoto, T. Nakaya
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引用次数: 13

Abstract

New segmented polyurethanes (SPUs) grafted phospholipid analogous vinyl monomers and polyfunctional monomers were synthesized. The soft segments used in this study were poly(butadiene). The hard segments of these polyurethanes were 4,4′-methylenediphenyl diisocyanate and 1,4-butanediol. The blood compatibilities of the new polymers were evaluated by platelet rich plasma (PRP) contact studies and viewed by scanning electron microscopy (SEM) using medical grade BioSpan and non-phospholipid polyurethane as a reference. The clotting times of the materials in contact with platelet poor plasma (PPP) were also measured. These results of two evaluations suggest that these grafted polymers may be regarded as hopeful biomaterials.

接枝磷脂类乙烯基单体和多官能团单体的新型分段聚氨酯的合成及其血液相容性
合成了接枝磷脂类乙烯基单体和多官能单体的新型节段聚氨酯(spu)。本研究使用的软段为聚丁二烯。这些聚氨酯的硬段是4,4 ' -亚甲基二苯二异氰酸酯和1,4-丁二醇。新聚合物的血液相容性通过富血小板血浆(PRP)接触研究进行评估,并通过扫描电子显微镜(SEM)观察,使用医用级BioSpan和非磷脂聚氨酯作为参考。同时测定了材料与血小板差血浆(PPP)接触时的凝血时间。这两项评价的结果表明,这些接枝聚合物可能被视为有希望的生物材料。
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