Herpes simplex virus type-specific antibodies detected by indirect and competition ELISA. Comparison of sera from patients with carcinoma of the uterine cervix, age matched controls and patients with recurrent genital herpes.

Abstract

A total of 85 human sera (32 from patients with carcinoma of the uterine cervix, 32 from matched controls, and 21 from patients with recurrent genital herpes) were tested in two different ELISAs for detection of HSV type-specific antibodies. The prevalence of HSV type 2 specific antibodies in the three groups were 69, 37 and 71% respectively. The prevalence of HSV type 1 specific antibodies in the three groups were 88, 75 and 76% respectively. Analysis of IgG and total antibodies gave identical results.