Pattern of serum brain-derived neurotrophic factor levels after acute interval exercise versus acute continuous exercise in obese adolescent females

IF 0.6 Q3 VETERINARY SCIENCES

Comparative Exercise Physiology Pub Date : 2022-10-14 DOI:10.3920/cep220017

S. Raharjo, P. S. Rejeki, A.W. Kurniawan, Widiastuti, M. S. Taufik, A. H. Siregar, A. Harisman, O. Andiana, H. Hidayati

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Abstract

Obesity has been linked to lower cognitive function, while exercise is known to be beneficial in enhancing the cognitive function. Exercise is also known to increase brain-derived neurotrophic factor (BDNF), as the biological marker of cognitive function. This study aimed to analyse the pattern of serum BDNF levels after acute interval exercise (MIE) versus acute continuous exercise (MCE) in obese adolescent females. A total of 24 obese females were enrolled in this study and given acute interval exercise and acute continuous exercise with moderate intensity. The serum level of BDNF in all samples was quantified using ELISA. Statistical analysis was performed using two-way repeated measures ANOVA, and LSD post-hoc test with a 5% significance level. The results revealed pre-exercise mean serum BDNF levels of 254.17±86.90 pg/ml (Control), 263.21±79.82 pg/ml (MIE) and 266.01±33.29 pg/ml (MCE) (P=0.948). The mean serum BDNF levels at 10 min post-exercise were 248.84±44.42 pg/ml (Control), 397.00±31.36 pg/ml (MIE), and 582.82±79.24 pg/ml (MCE) (P=0.000). The mean serum BDNF levels at 6 h post-exercise were 250.05±70.44 pg/ml (Control), 344.50±68.84 pg/ml (MIE), and 364.42±100.87 pg/ml (MCE) (P=0.029). The mean serum BDNF levels at 24 h post-exercise were 244.20±48.55 pg/ml (Control), 252.49±89.11 pg/ml (MIE), and 250.99±65.86 pg/ml (MCE) (P=0.986). It was concluded that serum BDNF in obese adolescent females increased but transiently. Serum BDNF levels increased by acute exercise in both MIE and MCE at 10 min and 6 h post-exercise. However, serum BDNF level at 24 h post-exercise decreased close to the pre-exercise serum BDNF level in all groups. Further research is needed studying the effect of chronic exercise on the kinetics of serum BDNF levels in obese adolescent females.

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青春期肥胖女性急性间歇运动与急性连续运动后血清脑源性神经营养因子水平的变化

肥胖与认知功能下降有关，而运动对增强认知功能有益。运动还可以增加脑源性神经营养因子(BDNF)，作为认知功能的生物学标志物。本研究旨在分析肥胖女性青少年急性间歇运动(MIE)和急性连续运动(MCE)后血清BDNF水平的变化模式。本研究共纳入24名肥胖女性，分别给予急性间歇运动和中等强度急性连续运动。采用ELISA法测定各组血清BDNF水平。统计学分析采用双向重复测量方差分析，LSD事后检验，显著性水平为5%。结果显示，运动前血清BDNF水平分别为对照组(254.17±86.90 pg/ml)、MIE组(263.21±79.82 pg/ml)和MCE组(266.01±33.29 pg/ml) (P=0.948)。运动后10 min血清BDNF水平均值分别为248.84±44.42 pg/ml(对照组)、397.00±31.36 pg/ml (MIE)和582.82±79.24 pg/ml (MCE) (P=0.000)。运动后6 h血清BDNF水平均值分别为250.05±70.44 pg/ml(对照组)、344.50±68.84 pg/ml (MIE)和364.42±100.87 pg/ml (MCE) (P=0.029)。运动后24 h血清BDNF水平均值分别为244.20±48.55 pg/ml(对照组)、252.49±89.11 pg/ml (MIE)和250.99±65.86 pg/ml (MCE) (P=0.986)。结论肥胖青少年女性血清BDNF升高，但为短暂性升高。在运动后10分钟和6小时，MIE和MCE的血清BDNF水平均因急性运动而升高。然而，在运动后24小时血清BDNF水平下降接近运动前各组血清BDNF水平。慢性运动对青春期肥胖女性血清BDNF水平的影响有待进一步研究。

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来源期刊

Comparative Exercise Physiology VETERINARY SCIENCES-

CiteScore

1.50

自引率

11.10%

发文量

期刊介绍： ''Comparative Exercise Physiology'' is the only international peer-reviewed scientific journal specifically dealing with the latest research in exercise physiology across all animal species, including humans. The major objective of the journal is to use this comparative approach to better understand the physiological, nutritional, and biochemical parameters that determine levels of performance and athletic achievement. Core subjects include exercise physiology, biomechanics, gait (including the effect of riders in equestrian sport), nutrition and biochemistry, injury and rehabilitation, psychology and behaviour, and breeding and genetics. This comparative and integrative approach to exercise science ultimately highlights the similarities as well as the differences between humans, horses, dogs, and other athletic or non-athletic species during exercise. The result is a unique forum for new information that serves as a resource for all who want to understand the physiological challenges with exercise.