THE GROWTH OF MESENCHYMAL STEM CELLS ON POLY(3-HYDROXYBUTYRATE) FILMS LOADED WITH LEVOFLOXACIN AND SIMVASTATIN

Abstract

Films were produced from a biodegradable and biocompatible polymer poly(3-hydroxybutyrate) loaded with the antibiotic levofloxacin (1% and 5% wt.) and the osteoinducer simvastatin (1% and 5% wt.). A study of the proliferation of mesenchymal stem cells on the surface of the prepared films showed that the poly(3-hydroxybutyrate) loaded with levofloxacin (1% and 5%) and simvastatin (1%) contribute to the maintenance of viability and proliferation of mesenchymal stem cells on the film surface, but on the films containing 5% simvastatin, inhibition of cell growth was ob-served. PHB-based drug systems have good prospects for use in bone tissue regeneration. лекарственные симвастатин, левофлоксацин.