Anti-Inflammation Effects of Rosmarinus Officinalis Extract Against Covid19 Virus ( In Silico Study)

Abstract

The critical condition of acute respiratory covid19 syndrome appeared to be the current health concern worldwide. It appeared at the beginning in Wuhan, China by end of 2019, soon after it spread to almost most of the global countries because of its high contagious properties. Precautionary procedures were the only helpful method to control the transmissions of person to person until any proper method of treatment or vaccine is established. Rosmarinus officinalis (RM) has strong anti-inflammation, anticancer and antibacterial effect. It is one of the probable choices of study against the outbreak of covid19 disease. In present article, we study in silico (molecular docking) characteristics of active compounds available in RM that is usually consumed as food additives and compare its biological effect with remdesivir and favipiravir as positive compounds based on docking properties. The actual active compounds in RM were selected based on their major roles in RM with desirable pharmacologic effects. The obtained results showed that both selected compounds were much stronger in inhibition of the studied proteins compared with remdesivir and favipiravir. Based on the combined scores in binding affinity, the drug-likeness properties of the ligands, showed to be better possible covid19 inhibitor compared with selected positive controls. The analysis of active site also showed that RM active compounds probably have the therapeutic efficacy against covid19 virus.