Multiple Changepoint Analysis of COVID-19 Infection Progression and Related Deaths in the Small Island State of Malta

D. Suda, M. Inguanez, Gianluca Ursino
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Abstract

In December 2019, in the city of Wuhan (China), Severe Acute Respiratory Syndrome Coronavirus - 2 (SARS-CoV−2), a virus that causes what is known as Coronavirus Disease 2019 (better known as COVID-19), emerged. In a few months the virus spread around the world becoming a global pandemic that has shaken the world. On Malta (a nation consisting of an archipelago of islands of approximately 500000 people), which is the case study of this analysis, the first case was identified on 7/3/2020. In this paper, we shall fit a piecewise linear trend model to the log-scale of cumulative cases and deaths due to COVID-19 in Malta by implementing the SN-NOT changepoint model. This model combines the self-normalisation (SN) technique, which is used to test whether there is a single change-point in the linear trend of a time series, with the Narrowest Over Threshold algorithm (NOT) to achieve multiple change-point in the linear trend. Through analysis of news reports and other sources of information, estimated change-points are then compared to potential factors such as health restrictions, mass events, government policy and population behaviour that have affected these changes, in order to determine the efffect of these factors on the spread of the disease.
小岛屿国家马耳他COVID-19感染进展和相关死亡的多变化点分析
2019年12月,在中国武汉市出现了严重急性呼吸综合征冠状病毒- 2 (SARS-CoV - 2),这是一种导致2019年冠状病毒病(更广为人知的是COVID-19)的病毒。几个月后,这种病毒在世界各地传播,成为一场震撼世界的全球大流行。在本分析的案例研究马耳他(一个由岛屿群岛组成的国家,人口约50万),第一例病例于2020年7月3日被发现。本文将采用SN-NOT变点模型对马耳他COVID-19累计病例和死亡人数的对数尺度拟合分段线性趋势模型。该模型结合了用于检验时间序列线性趋势中是否存在单个变化点的自归一化(SN)技术和用于检验线性趋势中是否存在多个变化点的最窄阈值算法(NOT)。通过分析新闻报道和其他信息来源,然后将估计的变化点与影响这些变化的潜在因素(如卫生限制、大规模事件、政府政策和人口行为)进行比较,以确定这些因素对疾病传播的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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