Influence of genotype and perioral musculature on maxillary and mandibular development.

The Angle orthodontist Pub Date : 2022-05-24 DOI:10.2319/112821-868.1

Sarah E Hansen, Joseph F A Petrone, John M Burnheimer, Alexandre R Vieira

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Abstract

Objectives: To determine whether there is an association between skeletal jaw position and perioral musculature, and if genotypes can predict skeletal growth.

Materials and methods: A prospective study on 42 patients over 1 year was performed. The study included 22 females and 20 males with and average age of 28.5 years. Lip strength was compared to radiographic cephalometric measurements. Allelic and genotypic frequencies from polymorphisms rs678397 and rs1815739 in ACTN3 and rs10850110 in MYO1H were compared to each variable. Chi-square and Fisher exact tests were used to determine if differences were statistically significant (alpha = 0.05).

Results: The data showed significant differences between rs678397 genotype and allele frequencies and SNA angle (P = .01; P = .003, respectively); between rs1815739 allele frequency and SNA angle (P = .01); between rs678397 allele frequency and ANB angle (P = .049); between rs678397 genotype and allele frequencies and lip strength in females (P = .045; P = .02); and between rs678397 allele frequency and overall lip strength (P = .049), after mean strength values used as cut off being customized by sex.

Conclusions: Polymorphisms in ACTN3 are associated with weak lips and larger SNA and ANB angles.

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基因型和口周肌肉组织对上颌骨和下颌骨发育的影响。

目的确定骨骼下颌位置与口周肌肉之间是否存在关联，以及基因型是否能预测骨骼的生长：对 42 名患者进行了为期一年的前瞻性研究。研究对象包括 22 名女性和 20 名男性，平均年龄为 28.5 岁。将唇部力量与放射学头颅测量结果进行了比较。将 ACTN3 的多态性 rs678397 和 rs1815739 以及 MYO1H 的多态性 rs10850110 的等位基因频率和基因型频率与每个变量进行了比较。结果显示，rs678397和rs1815739与MYO1H的rs10850110之间存在显著差异：数据显示，rs678397 基因型和等位基因频率与 SNA 角之间存在显著差异（分别为 P = .01; P = .003）；rs1815739 等位基因频率与 SNA 角之间存在显著差异（P = .01）；rs678397 等位基因频率与 ANB 角之间存在显著差异（P = .049）之间；rs678397基因型和等位基因频率与女性嘴唇强度之间（P = .045；P = .02）；以及rs678397等位基因频率与总体嘴唇强度之间（P = .049），以平均强度值作为分界点后按性别进行定制：结论：ACTN3 的多态性与嘴唇薄弱、SNA 和 ANB 角度较大有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Angle orthodontist

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