Comparison of Bacterial Etiology with Antibiogram of Blood Stream Infection between Adult and Paediatric Group at a Tertiary Care Hospital in Bangladesh

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Bangladesh Journal of Medical Science Pub Date : 2023-09-07 DOI:10.3329/bjms.v22i4.67126

Tarana Jahan, Md Abdullah Yusuf, S. Shahid, Siddika Khatun, S. Sultana, Kajol Akter, Anika Farzin, SM Moniruzzaman

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Abstract

Background: Timely understanding of bacterial profiles and the change of antimicrobial resistance provide an important guidance for effective and optimized use of antibiotics in local healthcare systems. Objective: The purpose of this study was to compare of bacterial etiology with antibiogram of blood stream infection between adult and paediatric. Methodology: This cross-sectional study was conducted in the department of Microbiology at Monno Medical College, Manikganj, Bangladesh during the period from January 2019 to December 2019 for duration of one year. In adult and pediatric patient blood was collected according to blood collection guidelines and inoculated into BacT/ALERT FA plus and BacT/ALERT PF plus aerobic blood culture bottles respectively. After collection these bottles were immediately incubated in BacT/ALERT 3D (manufactured by bioMerieoux, France) a fully automated blood culture system. Antimicrobial susceptibility test was done for all isolated bacteria by disc diffusion method. Result: A total number of 178 patients were recruited, among them 12 (7%) yielded growth of different bacteria. The culture positive cases were found in 7 (4%) in Paediatric group and 5 (3%) in adult age group. The most predominant identified bacteria in Paediatric group was Escherichia Coli which showed highly sensitive to imipenum, amikacin, linezolid, gentamicin (n=3, 100%). In adult group the most predominant isolated bacteria was Streptococci species which showed high sensitive to imipenum, linezolid, gentamicin 4 (80%) considerable sensitive to ciprofloxacin, tetracycline, cefotaxime, cefuroxime 3(60.0%). Conclusion: In conclusion the most common bacteria isolated from blood stream infection in adult and paediatric group are Streptococci species and Escherichia Coli respectively. Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 869-875

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孟加拉国某三级医院成人组与儿科组血流感染细菌病原学与抗生素谱比较

背景:及时了解细菌特征和抗菌药物耐药性变化对当地卫生保健系统有效和优化使用抗生素具有重要指导意义。目的:本研究的目的是比较成人和儿童血流感染的细菌病因学和抗生素谱。方法:本横断面研究于2019年1月至2019年12月在孟加拉国Manikganj Monno医学院微生物学系进行，为期一年。成人和儿童患者按照采血指南采血，分别接种于BacT/ALERT FA +和BacT/ALERT PF +有氧血培养瓶中。收集后，这些瓶子立即在BacT/ALERT 3D(法国bioMerieoux公司制造)全自动血液培养系统中孵育。所有分离菌均采用纸片扩散法进行药敏试验。结果:共纳入178例患者，其中12例(7%)产生不同细菌。儿童组培养阳性7例(4%)，成人组培养阳性5例(3%)。儿科组以大肠杆菌为主，对亚胺培南、阿米卡星、利奈唑胺、庆大霉素高度敏感(n=3, 100%)。成虫组以链球菌为主，对亚胺培南、利奈唑胺、庆大霉素4高度敏感(80%)，对环丙沙星、四环素、头孢噻肟、头孢呋辛3相当敏感(60.0%)。结论:成人和儿童血流感染中分离到的最常见细菌分别是链球菌和大肠杆菌。孟加拉国医学杂志，第22卷第4期，23年10月，第869-875页

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