INFLUENCE OF THE TECHNOGENIC STRESS ON CARBOHYDRATE-CONTAINING LIVER BIOPOLYMERS OF RATS WITH DIFFERENT SENSITIVITY TO STRESS

Abstract

Introduction. As H. Selye noted in his works, the influence of factors of various etiologies can act on humans and cause a complex complex response of the body in the form of a stress reaction, and as a result, the development of imbalance of regulatory physiological systems. Purpose. Studied the impact of the effect of a technogenic rotating electric field (REF) on the content of carbohydrate-containing liver biopolymers in animals with different sensitivity to stress. Material and methods. The experiments were carried out on 36 male rats. In the liver homogenate, the levels of sialic acids (SA), mucoproteins (MP), fucose (FC) and -L-fucosidase (-L-F) were determined before, on the 10th and 20th day of REF exposure. Prior to the study, animals were diagnosed by the "open field" method to determine stress resistance and were differentiated into groups: stress resistant (SR), stress unstable (SU) and ambivalent (SA). Results. On the 10th day of exposure to REF in the liver homogenate in all rats, an increase in all the studied parameters was noted, which is typical for catabolic processes. Namely, an increase in the concentration of SA: in SR 14% (p=0,02), SU 29% (p=0,02), SA 26% (p=0,02). The FC content increased by 24% (p=0,01) in SR individuals, 27% (p=0,01) in SU, and 31% (p=0,01) in SA. There was an increase in the activity of -L-F, in SR 55% (p=0,02), in SU 63% (p=0,02), in SA 55% (p=0,02). MP level increased and amounted to 58% (p=0,01) in SR, 76% (p=0,01) in SU, and 65% (p=0,02) in SA. The most pronounced catabolic processes were observed in the SU group of individuals. By the 20th day of the experiment, the severity of the processes of decomposition of carbohydrate-containing biopolymers decreased in all groups. Conclusion. The results of the study demonstrate that a technogenic rotating electric field changes the content of carbohydrate-containing biopolymers in the liver of animals, contributing to the activation of catabolic processes, the severity of which depends on the initial sensitivity to stress.