Relationship between age and cellular suppressive activity in resistance to Histoplasma capsulatum infection.

Sabouraudia Pub Date : 1985-01-01 DOI:10.1080/00362178585380511

M. R. R. Reyes Montes, J. Casasola, N. Elizondo, M. L. Taylor

{"title":"Relationship between age and cellular suppressive activity in resistance to Histoplasma capsulatum infection.","authors":"M. R. R. Reyes Montes, J. Casasola, N. Elizondo, M. L. Taylor","doi":"10.1080/00362178585380511","DOIUrl":null,"url":null,"abstract":"One-month-old and 1-year-old male BALB/c mice showed a lower resistance than 4.5-month-old mice to Histoplasma capsulatum infection. 4.5-month-old mice successfully resolved the infection when challenged with either a LD50 or LD100 for 1-month-old mice. A critical clinical course of experimental histoplasmosis was observed in 4.5-month-old syngeneic mice when spleen cells from 1-month-old BALB/c mice were transferred to them. Irradiated recipient mice, into which bone marrow and spleen cells were transferred, died when infected with the LD100 for 1-month-old mice. The same occurred with 4.5-month-old non-irradiated infected mice which received only spleen cells and with 1-month-old mice which were used as a control of infection. However, infected and non-transferred 4.5-month-old mice survived this dose. Thus, the adoptive transference of spleen cells from 1-month-old mice to 4.5-month-old mice suppressed the resistance of these adult mice to infection. Apparently, the transference of the suppressive state requires the presence of two cell populations, a non-adherent and an adherent and radioresistant cell present in the spleen of male 1-month-old mice.","PeriodicalId":21469,"journal":{"name":"Sabouraudia","volume":"16 1","pages":"351-60"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sabouraudia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/00362178585380511","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 4

Abstract

One-month-old and 1-year-old male BALB/c mice showed a lower resistance than 4.5-month-old mice to Histoplasma capsulatum infection. 4.5-month-old mice successfully resolved the infection when challenged with either a LD50 or LD100 for 1-month-old mice. A critical clinical course of experimental histoplasmosis was observed in 4.5-month-old syngeneic mice when spleen cells from 1-month-old BALB/c mice were transferred to them. Irradiated recipient mice, into which bone marrow and spleen cells were transferred, died when infected with the LD100 for 1-month-old mice. The same occurred with 4.5-month-old non-irradiated infected mice which received only spleen cells and with 1-month-old mice which were used as a control of infection. However, infected and non-transferred 4.5-month-old mice survived this dose. Thus, the adoptive transference of spleen cells from 1-month-old mice to 4.5-month-old mice suppressed the resistance of these adult mice to infection. Apparently, the transference of the suppressive state requires the presence of two cell populations, a non-adherent and an adherent and radioresistant cell present in the spleen of male 1-month-old mice.

查看原文本刊更多论文

抗荚膜组织浆体感染细胞抑制活性与年龄的关系。

1月龄和1月龄雄性BALB/c小鼠对荚膜组织浆体感染的抵抗力低于4.5月龄小鼠。用LD50或LD100刺激1个月大的小鼠，4.5月龄的小鼠成功地解决了感染。将1月龄BALB/c小鼠的脾脏细胞移植到4.5月龄的同基因小鼠身上，观察到实验性组织胞浆菌病的关键临床过程。将骨髓和脾脏细胞移植到受辐照的受体小鼠中，在感染1个月大的LD100小鼠后死亡。同样的情况也发生在仅接受脾脏细胞的4.5月龄未辐照感染小鼠和作为感染对照的1月龄小鼠身上。然而，感染和未转移的4.5个月大的小鼠在这种剂量下存活下来。因此，将1月龄小鼠的脾细胞过继移植到4.5月龄小鼠体内，抑制了这些成年小鼠对感染的抵抗力。显然，抑制状态的转移需要两个细胞群的存在，一个非粘附细胞和一个存在于1月龄雄性小鼠脾脏中的粘附和耐辐射细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Sabouraudia

自引率

0.00%

发文量