Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review

Abstract

The exact pathogenesis of Alzheimer’s disease is still a matter to debate, currently there is no reliable therapy established for Alzheimer’s disease. However, several pieces of evidence suggest that the use of plant based phytoconstituents mainly delays the onset of Alzheimer. So, in this review, we collect information about the cause of Alzheimer’s disease hypothesis and neuroprotective effect of phytoconstituents. This review paper aimed to analyze the current pathogenesis of Alzheimer’s disease and the therapeutic effect of plant phytoconstituents that play a vital role in neuroprotective and antistress activities in Alzheimer’s disease and other neurodegenerative disorders. The source of literature review obtained from Scopus, Science direct, PubMed, web of science database, and journal by using Alzheimer’s pathogenesis, neuroinflammation, oxidative stress, amyloid beta, flavonoids, alkaloids are important part of these review research. The current review explored the different types of pathogenesis involved in Alzheimer’s disease and the role of phytoconstituents in treatment of it. The collected information showed that plant based constituents inhibit the major cause of Alzheimer’s disease related to amyloid beta, tau protein, oxidative stress, neuroinflammation etc. The study provide the clue for the investigation of eminent bioactive constituents may serves as an alternative candidate against Alzheimer’s disease and other neurodegenerative disorders.