CHAPTER 9. Soft Forces in Organic Synthesis by C–N Coupling Reactions

A. Bose, Saikat Maiti, P. Mal
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引用次数: 5

Abstract

Chemical reactions controlled by the systems involved are essential to elucidate the complex functions of living systems and create new functional molecules. This chapter proposes the utilization of simultaneous cooperative multiple weak interactions or soft forces in the synthesis of C–N bonds. In general, metal-mediated synthetic methods for the syntheses of C–N bonds are associated with drawbacks, e.g. (a) requirements for prefunctionalized starting materials, for example aryl halides, prior to the amination (making overall transformation multi-step in nature), and (b) production of stoichiometric amounts of metal halides as waste after the amination. In contrast, by performing C–N coupling reactions via direct C–H activation or functionalization (without using any prefunctionalized systems), many amination reactions can be successfully achieved. This chapter mainly covers selective C–N bond formation reactions under mild conditions with the intention that the reactivity of those systems could be controlled through soft forces or cooperative noncovalent interactions.
第9章。C-N偶联反应有机合成中的软力
由相关系统控制的化学反应对于阐明生命系统的复杂功能和创造新的功能分子是必不可少的。本章提出了同时协同多重弱相互作用或软力在C-N键合成中的应用。一般来说,用于合成C-N键的金属介导合成方法存在缺陷,例如(a)在胺化之前需要预功能化的起始材料,例如芳基卤化物(使得整体转化在性质上是多步骤的),以及(b)在胺化之后产生化学量的金属卤化物作为废物。相比之下,通过直接C-H活化或功能化(不使用任何预功能化系统)进行C-N偶联反应,可以成功地实现许多胺化反应。本章主要介绍在温和条件下的选择性C-N键形成反应,目的是通过软力或合作非共价相互作用来控制这些系统的反应性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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