Pharmaceutical companies must make decisions based on profit.

Lawrence Perkins
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As with every company, for them to exist, they must ensure that the result of the following equation is greater than zero: \n \n \n \n \n \n \n \n \nFor them to operate, the management must generate the highest level of profitability possible to fulfill its fiduciary duty of maximizing shareholder value. \n \nChandrasoma argues that pharmaceutical companies have an obligation to society to produce medicines that address all afflictions and to avoid discriminating against a particular disease or condition. But pharmaceutical companies have to discriminate because, like other commercial enterprises, every day they must answer the following question: can we afford this venture? This decision must be based purely on sales and costs. \n \nAs any consumer knows, pharmaceuticals are expensive to purchase. Treatments for HIV infection can cost thousands of dollars per year. The reason for these high costs is the tremendous amount of time and money necessary to develop, approve, and distribute these medications. \n \nOver the past 10 years, Bristol-Meyers Squibb has spent more than 10% of its total sales on research and development.1 Merck alone spent more than $9.4 billion on research and development between 1996 and 2000.2 To put things in perspective, Merck could hand every American citizen a $5 bill or purchase every good produced in Tanzania for less than they have spent in 5 years on research and development. \n \nOnce the research and development is complete, pharmaceutical companies can expect to spend many billions more on clinical trials, political lobbying, and other costs associated with launching a new product. On top of that, they must wait, on average, 10 years to begin selling the products and recouping cost. \n \nThe revenue generated from a successful product must recover the cost of not only that product's research and development but also the cost of failed ventures. Companies can either charge phenomenally high prices for drugs that affect relatively small patient populations (for example, patients in the United States with AIDS or multiple sclerosis) or charge a more commercially viable price for drugs that address the needs of a huge portion of the population (for example, those with erectile dysfunction or allergies). Based on the medical system that is currently in place, insurance companies are more likely to lobby against high-priced treatments to ward off the consequent increase in reimbursement costs and subsequent hikes in premiums. As such, it is much more commercially viable to produce “little blue pills” for $10 a pop that appeal to (statistically) every man at some point in his life. \n \nIs there a solution? As usual, the answer is “It depends.” Like the problem, the solution can be addressed from the cost and sales side. From the cost side, if the pharmaceutical companies are relieved of their fiduciary duty or are supplied with the research money necessary to generate these drugs, they will be elated to capitalize on any opportunity possible. Similarly, if the insurance companies will alter their lobbying strategies and verify that they will pay high prices for cutting-edge drugs for rare sicknesses, the scientists and researchers at the pharmaceutical companies will gladly return to the lab. \n \nPharmaceutical companies are easily vilified, but the decisions they make regarding drug production are based on fiduciary instead of medical decisions. Although the system is admittedly flawed, to scapegoat any one component is counterproductive to long-term progress in health care.","PeriodicalId":22925,"journal":{"name":"The Western journal of medicine","volume":"17 1","pages":"422-423"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Western journal of medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/EWJM.175.6.422","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

To criticize pharmaceutical companies for researching and marketing medications for some diseases but not others is akin to criticizing Victoria's Secret for biasing their line of products primarily toward women. Regardless of what a company is selling, they are in the business of making money and satisfying their fiduciary duties. Whether the company is pedaling widgets, cigarettes, or other companies, at the end of the day the company's future existence depends on the bottom line of the income statement. Pharmaceutical companies are no different. They are in the business of making money by selling pharmaceuticals. As with every company, for them to exist, they must ensure that the result of the following equation is greater than zero: For them to operate, the management must generate the highest level of profitability possible to fulfill its fiduciary duty of maximizing shareholder value. Chandrasoma argues that pharmaceutical companies have an obligation to society to produce medicines that address all afflictions and to avoid discriminating against a particular disease or condition. But pharmaceutical companies have to discriminate because, like other commercial enterprises, every day they must answer the following question: can we afford this venture? This decision must be based purely on sales and costs. As any consumer knows, pharmaceuticals are expensive to purchase. Treatments for HIV infection can cost thousands of dollars per year. The reason for these high costs is the tremendous amount of time and money necessary to develop, approve, and distribute these medications. Over the past 10 years, Bristol-Meyers Squibb has spent more than 10% of its total sales on research and development.1 Merck alone spent more than $9.4 billion on research and development between 1996 and 2000.2 To put things in perspective, Merck could hand every American citizen a $5 bill or purchase every good produced in Tanzania for less than they have spent in 5 years on research and development. Once the research and development is complete, pharmaceutical companies can expect to spend many billions more on clinical trials, political lobbying, and other costs associated with launching a new product. On top of that, they must wait, on average, 10 years to begin selling the products and recouping cost. The revenue generated from a successful product must recover the cost of not only that product's research and development but also the cost of failed ventures. Companies can either charge phenomenally high prices for drugs that affect relatively small patient populations (for example, patients in the United States with AIDS or multiple sclerosis) or charge a more commercially viable price for drugs that address the needs of a huge portion of the population (for example, those with erectile dysfunction or allergies). Based on the medical system that is currently in place, insurance companies are more likely to lobby against high-priced treatments to ward off the consequent increase in reimbursement costs and subsequent hikes in premiums. As such, it is much more commercially viable to produce “little blue pills” for $10 a pop that appeal to (statistically) every man at some point in his life. Is there a solution? As usual, the answer is “It depends.” Like the problem, the solution can be addressed from the cost and sales side. From the cost side, if the pharmaceutical companies are relieved of their fiduciary duty or are supplied with the research money necessary to generate these drugs, they will be elated to capitalize on any opportunity possible. Similarly, if the insurance companies will alter their lobbying strategies and verify that they will pay high prices for cutting-edge drugs for rare sicknesses, the scientists and researchers at the pharmaceutical companies will gladly return to the lab. Pharmaceutical companies are easily vilified, but the decisions they make regarding drug production are based on fiduciary instead of medical decisions. Although the system is admittedly flawed, to scapegoat any one component is counterproductive to long-term progress in health care.
制药公司必须根据利润做出决策。
批评制药公司研究和销售针对某些疾病的药物,而不是针对其他疾病的药物,就像批评维多利亚的秘密(Victoria’s Secret)将其产品线主要面向女性一样。不管一家公司卖的是什么,他们都是在赚钱和履行他们的受托责任。不管这家公司是在推销小工具、香烟还是其他公司,说到底,这家公司未来的生存取决于损益表的底线。制药公司也不例外。他们从事卖药赚钱的生意。就像所有公司一样,为了生存,他们必须确保以下等式的结果大于零:为了经营,管理层必须产生最高水平的盈利能力,以履行其股东价值最大化的受托责任。Chandrasoma认为,制药公司有义务生产治疗所有疾病的药物,并避免歧视特定疾病或病症。但制药公司必须歧视,因为像其他商业企业一样,他们每天都必须回答以下问题:我们能承担得起这个冒险吗?这个决定必须完全基于销售和成本。任何消费者都知道,购买药品是很贵的。治疗HIV感染每年要花费数千美元。这些高成本的原因是开发、批准和分发这些药物所需的大量时间和金钱。在过去的10年里,百时美施贵宝将其总销售额的10%以上用于研发从1996年到2000年,仅默克公司就在研发上花费了94亿美元。从长远来看,默克公司可以给每个美国公民一张5美元的钞票,或者用比他们5年在研发上花的钱还少的钱购买坦桑尼亚生产的所有产品。一旦研发完成,制药公司可能会在临床试验、政治游说以及与推出新产品相关的其他成本上花费数十亿美元。最重要的是,他们必须平均等待10年才能开始销售产品并收回成本。一款成功产品所产生的收入不仅要弥补该产品的研发成本,还要弥补失败企业的成本。公司可以对影响相对较小的患者群体的药物(例如,美国的艾滋病患者或多发性硬化症患者)收取非常高的价格,也可以对满足大部分人群需求的药物(例如,勃起功能障碍或过敏症患者)收取更具商业可行性的价格。根据目前的医疗制度,保险公司更有可能游说反对高价治疗,以避免报销费用的增加和随后的保费上涨。因此,在商业上更可行的做法是,以每支10美元的价格生产“蓝色小药丸”,吸引(统计上)每个男人在他生命中的某个阶段。有解决办法吗?和往常一样,答案是“看情况而定”。与问题一样,解决方案可以从成本和销售方面着手。从成本方面来看,如果制药公司解除了他们的受托责任,或者获得了生产这些药物所需的研究资金,他们就会兴高采烈地利用任何可能的机会。同样,如果保险公司改变他们的游说策略,并证实他们愿意为治疗罕见疾病的尖端药物支付高价,制药公司的科学家和研究人员就会很高兴地回到实验室。制药公司很容易受到诋毁,但他们做出的有关药品生产的决定是基于信托而不是医疗决定。尽管该系统无可否认存在缺陷,但将任何一个组成部分作为替罪羊,都不利于医疗保健的长期进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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