Evaluation of effect of aqueous slurry of Curculigo orchioides Gaertn. rhizome in streptozotocin-induced diabetic rats

Journal of Pharmacy Research Pub Date : 2013-08-01 DOI:10.1016/j.jopr.2013.08.016

Avinash Patil , Swapneel Koli , Darshana A. Patil , Vinod Narayane , Anita V. Phatak

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引用次数: 6

Abstract

Aim

The present study was undertaken to carry out phytochemical analysis and to investigate the antihyperglycaemic effect of aqueous slurry of Curculigo orchioides Gaertn. rhizome powder (ASCO) for 21 days.

Method

Diabetes was induced in Albino Wistar rats by single intraperitoneal administration of streptozotocin (50 mg/kg body weight). Normal as well as diabetic rats were divided into four groups to receive different treatments.

Result

Preliminary phytochemical analysis showed presence of glycosides, mucilage, tannins, steroids, flavonoids, saponins and essential oils. Phytochemical analysis using TLC showed presence of arbutin, bitter principles, cardiac glycosides, coumarins, essential oils, lignans, pungent-tasting principles, saponins, triterpenes and valepotriates. Acute toxicity study in rats did not show any signs of toxicity up to the dose of 2000 mg/kg body weight. In STZ induced diabetic rats, the daily oral treatment with ASCO (1000 mg/kg body weight) showed a significant reduction in blood glucose level. STZ administration severely deteriorated the histological structures of pancreas, kidney and liver of diabetic rats, which were found to be restored to certain extent in glibenclamide and ASCO treated animals.

Conclusion

The study indicated that ASCO is a potential antidiabetic agent and lends scientific support for its use in folk medicines.

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莪术水浆的效果评价。链脲佐菌素诱导的糖尿病大鼠的根茎

目的对莪术水浆进行植物化学分析，探讨莪术水浆的降糖作用。根茎散(ASCO) 21 d。方法采用单次腹腔注射链脲佐菌素(50 mg/kg体重)诱导白化Wistar大鼠糖尿病。将正常大鼠和糖尿病大鼠分为四组，分别给予不同的治疗。结果初步植物化学分析显示，黄芪中含有苷类、粘液类、单宁类、甾体类、黄酮类、皂苷类和精油。薄层色谱分析显示，其中含有熊果苷、苦苷、心苷、香豆素、精油、木脂素、刺激性成分、皂苷、三萜和戊酸酯。在大鼠急性毒性研究中，直到2000mg /kg体重的剂量未显示任何毒性迹象。STZ诱导的糖尿病大鼠，每日口服ASCO (1000 mg/kg体重)可显著降低血糖水平。STZ给药严重恶化了糖尿病大鼠胰腺、肾脏和肝脏的组织结构，而格列本脲和ASCO处理的大鼠胰腺、肾脏和肝脏组织结构均有一定程度的恢复。结论ASCO是一种潜在的降糖药，为其在民间药物中的应用提供了科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Pharmacy Research

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