Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder

F. Nery, A. D. Gigante, J. Amaral, Francy B. F. Fernandes, Mariangeles Berutti, K. M. Almeida, L. Stertz, G. Bristot, F. Kapczinski, B. Lafer
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引用次数: 8

Abstract

Objective: Unaffected relatives of bipolar disorder (BD) patients have been investigated for the identification of endophenotypes in an attempt to further elucidate the pathophysiology of the disease. Brain-derived neurotrophic factor (BDNF) is considered to be implicated in the pathophysiology of BD, but its role as an endophenotype has been poorly studied. We investigated abnormal serum BDNF levels in BD patients, in their unaffected relatives, and in healthy controls. Methods: BDNF levels were obtained from 25 DSM-IV bipolar I disorder patients, 23 unaffected relatives, and 27 healthy controls. All BD patients were in remission. The unaffected subjects were first-degree relatives of the proband who had no lifetime DSM-IV diagnosis of axis I disorder. BDNF serum levels were determined by sandwich ELISA using monoclonal BDNF-specific antibodies. Results: There were no statistical differences in BDNF levels among BD patients, relatives, and healthy controls. Conclusion: Serum BDNF levels may not indicate high genetic risk for BD, possibly acting as state markers rather than trait markers of the disease.
双相情感障碍患者未受影响的一级亲属血清BDNF水平
目的:对双相情感障碍(BD)患者未受影响的亲属进行调查,以鉴定其内表型,试图进一步阐明该疾病的病理生理。脑源性神经营养因子(BDNF)被认为与双相障碍的病理生理有关,但其作为一种内表型的作用研究甚少。我们调查了BD患者、其未受影响亲属和健康对照者血清BDNF水平的异常。方法:采集25例DSM-IV双相情感障碍患者、23例未患病亲属和27例健康对照者的BDNF水平。所有BD患者均缓解。未受影响的受试者为先证者的一级亲属,且终生未在DSM-IV中诊断出I轴障碍。采用单克隆BDNF特异性抗体夹心ELISA法检测血清BDNF水平。结果:BDNF水平在BD患者、亲属和健康对照组之间无统计学差异。结论:血清BDNF水平可能并不表明双相障碍的高遗传风险,可能作为该疾病的状态标记而不是性状标记。
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