Assessment of Analgesic, Cytotoxic and Antioxidant activities of Vallaris solanacea (Roth) Kuntze

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-11-07 DOI:10.3329/SJPS.V4I1.8869

U. Karmakar, Dyuti Ghosh, S. K. Sadhu

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引用次数: 6

Abstract

The ethanolic extract of leaves and stem of Vallaris solanacea (Roth) Kuntze (Family: Apocynaceae) was screened for its analgesic, cytotoxic and antioxidant activities. Phytochemical analysis of the extract indicated the presence of Reducing Sugar, Tannins, Saponins, Gums, Steroids, Alkaloids, and Glycosides. The ethanolic extract showed statistically significant analgesic activity (p<0.005) in acetic acid induced writhing inhibition in mice at the dose of 500mg/kg body weight and also showed mild effect at the doses of 250mg/kg body weight. In the brine shrimp lethality test, the extract showed cytotoxicity with LC 50 80 μg/ml and LC 90 320 μg/ml. In the qualitative antioxi-dant assay using DPPH (1, 1-diphenyl-2-picryl hydrazyl) the extract showed free radical scavenging properties. These primary findings suggest that the extract might possess some chemical constituents that are responsible for analgesic, cytotoxic and antioxidant activities. Key words : Vallaris solanacea (Roth) Kuntze; phytochemical study; analgesic activity; cytotoxic activity; antioxi-dant activity. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8869 SJPS 2011; 4(1): 64-68

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荆芥的镇痛、细胞毒和抗氧化活性评价

对罗布麻科缬草(valallaris solanacea, Roth)茎叶乙醇提取物进行了镇痛、细胞毒和抗氧化活性的筛选。植物化学分析表明，提取物中含有还原糖、单宁、皂苷、树胶、类固醇、生物碱和糖苷。在500mg/kg体重剂量下，乙醇提取物对小鼠醋酸致扭体抑制作用有统计学意义(p<0.005);在250mg/kg体重剂量下，乙醇提取物对小鼠醋酸致扭体抑制作用较弱。在盐水对虾致死试验中，提取物的lc50 80 μg/ml和lc90 320 μg/ml具有细胞毒性。在DPPH(1,1 -二苯基-2-苦味基肼)定性抗氧化实验中，提取物显示出清除自由基的特性。这些初步发现表明，该提取物可能含有一些具有镇痛、细胞毒和抗氧化活性的化学成分。关键词:昆姿缬草;植物化学的研究;镇痛活动;细胞毒性活动;antioxi-dant活动。DOI: http://dx.doi.org/10.3329/sjps.v4i1.8869 SJPS 2011;4 (1): 64 - 68

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Stamford Journal of Pharmaceutical Sciences

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