Modulation of immune system parameters during the development of glutamate-induced steatohepatosis and its correction with multiprobiotic «Symbiter acidophilic» concentrated

Abstract

. The energy metabolism disorder which triggers immunological functions depression which can be manifested by cytokine dysregulation, change of functioning of the cellular components of the immune system with activation of humoral component resulting in hyperglobulinemia is found in clinical trials of type 2 diabetes and obesity. The developmental mechanisms and impact of immunological changes on the processes still remain undefined. It has been established that the visceral obesity without hyperphagia manifestations, accompanied by dyslipidemia, disturbed sensitivity of the peripheral tissue to insulin and hepatic steatosis development, being confirmed by morphological methods and morphometric analysis and shear wave elasticity imaging (SWEI), was registered in 4-month-old rats with neonatal injection of sodium glutamate. The splenic weight and the number of splenocytes in 4-month-old rats with neonatal injection of sodium glutamate decreased secondary to the development of visceral obesity and hepatic steatosis, which resulted in the immune system dysfunction one of the manifestations of which was a dysbal-ance of the content of pro- and anti-inflammatory cytokines in blood serum of the rats. The periodic administration of the multi-probiotic «Symbiter® acidophilic» concentrated in rats with glutamate-induced hepatic steatosis triggered the significant restoration of the morphological functional liver condition and the prevention of the hepatic steatosis development.