A Cross Sectional Analysis about relation of Serum Uric Acid with other Cardiovascular risk factors

Abstract

Introduction: The positive association between serum uric acid and cardiovascular diseases such as stroke or ischemic heart disease has been recognized since the 1950s and has been confirmed by numerous epidemiological studies.Elevated serum uric acid levels are commonly seen in association with glucose intolerance, hypertension and dyslipidemia, a cluster of metabolic and hemodynamic disorders which characterize the so-called metabolic syndrome.The purpose of the present study was to investigate the prevalence and the clinical correlates of hyperuricemia. Methods:This Cross Sectional  analytical  study involved Prior Consent from the patients & was found to be within ethical standards. It was conducted in six  months. Simple random sampling technique was used for data collection. An Interview with the help of Predesigned Questionnaire along with detailed clinical Examination was done. Cutt off Limits of various Cardiovascular risk factors was set . . 300 Number of Patients were included in the study. Results: In both sexes, serum triglycerides and serum uric acid levels were strongly correlated (p < 0.001). In women, significant correlations (p < 0.01) were also found with almost all metabolic parameters except for alcohol consumption. In men, serum uric acid correlated with blood pressure, body mass Index and  total cholesterol (p < 0.01). Age, triglycerides, BMI, alcohol consumption and hypertension were the major determinants of the variations in serum uric acid levels in both sexes. Conclusion: Hyperuricemia is also closely linked to the various components of the metabolic syndrome and in particular to serum triglycerides. Considering the rapidly increasing incidence of obesity and metabolic syndrome around the World and the potential link between hyperuricemia and coronary heart disease or stroke, more emphasis should be put on the evolving prevalence of hyperuricemia in developing countries.