外泌体生物学特性及其在肝癌中的作用研究 Biological Characteristics of Exosomes and Their Role in Hepatocellular Carcinoma

Abstract

肝细胞癌(HCC)发生发展的分子机制尚未完全清楚，可能涉及病毒致癌作用、癌基因和抑癌基因失活、癌细胞凋亡等。外泌体能介导细胞间物质传递和信息交流，在多种癌症发生发展中起着重要作用。本文旨在总结外泌体生物学特性及其在肝癌发生发展、诊断和治疗中的作用。 The mechanism of hepatocellular carcinoma (HCC) development is not yet fully understood, which may be related to the carcinogenesis of the virus, the inactivation of oncogenes and tumor sup-pressor genes, cancer cell apoptosis. Exosomes, which can mediate the material transfer between cells and the exchange of information, play significant roles in the occurrence and development of a variety of cancers. This article aims to summarize the biological characteristics of exosomes and their roles in the development, diagnosis and treatment of HCC.