Cystatin C as the Predictor of Chronic Kidney Disease in Patients with Comorbid Pathology

Abstract

Materials and methods: 383 patients with comorbid pathology aged from 25 to 88 years (mean age 58.8±12.0 years) were examined, of whom 51.4% were men and 48.6% women. In the structure of comorbid pathology, arterial hypertension (AH) was observed in 76.5%, coronary heart disease (CHD) in 48.8%, diabetes mellitus (DM) type2 in 29.7%, obesity in 47, 5% and chronic obstructive pulmonary disease (COPD) in 28.9% of patients. The examined patients were divided into 4 groups: 1st persons with hypertension+type2 diabetes (n = 99); 2nd AH + CHD (n = 138); 3rd -AH + COPD (n = 102) and the 4th group patients with severe comorbid pathology, i.e. AH + DM + CHD + COPD (n = 44). All patients were studied for lipid spectrum parameters [total cholesterol (cholesterol), high-density lipoprotein cholesterol (HDL cholesterol), low-density lipoprotein cholesterol (LDL cholesterol), triglycerides (TG)] and cystatin C of blood plasma. The glomerular filtration rate (GFR) was calculated according to the formula F.J. Hoek. The severity of renal dysfunction was assessed according to the recommendation of KDIGO (Kidney Disease: Improving Global Outcomes) 2012. The analysis of the prevalence of reduced GFR in patients with comorbid pathology was also carried out.