THE EFFECTIVENESS OF IMMUNOMODULATORS TO CREATE A PROTECTIVE EFFECT AGAINST THE LEUKEMIA VIRUS IN CALVES

Abstract

The work was carried out in the laboratory of veterinary medicine VNIIOK - a branch of the Federal State Budgetary Scientific Institution "North Caucasian FNAC", as well as in the farms of the Kochubeevsky district of the Stavropol Territory. The object of the study was cattle of various age groups, blood and its serum. 4 groups of 12 animals each were created: 1st group: newborn calves; 2nd group: calves 4-6 months; 3rd group: heifers (15-18 months); 4th group: cows 4-5 years old. Each group was divided into 4 subgroups of 3 animals, while the 1st subgroup received Immunofan, the 2nd subgroup - Biferon-B, the 3rd - Ligfol, the 4th - control, the animals of which were injected with sterile saline. Analyzing the dynamics of hematological parameters of infected newborn calves and calves 4-6 months. of age, it should be noted that the immunomodulators Immunofan and Biferon-B provoke prolonged leukocytosis in the physiological range. In the 1st subgroup of calves, by the 14th day of the experiment, the ESR decreased significantly. The use of Ligfol in calves contributed to an increase in the level of hemoglobin in the blood. Immunotherapy with Immunofan and Biferon-B of VL-infected heifers contributed to a decrease in the level of leukocytes and ESR, Ligfol caused a decrease in ESR and an increase in hemoglobin. The use of Immunofan and Biferon-B preparations in infected cows 4-5 years old provoked leukocytosis, a decrease in ESR, Ligfol activated hematopoiesis and contributed to a decrease in ESR, but the changes were not prolonged. The conducted studies allow us to draw the main conclusions: the use of immunomodulators Immunofan and Biferon-B to VL-infected young animals from birth to 4-6 months contributes to the normalization of the clinical condition and activates the immune system; helps to reduce the number of infected livestock (newborn calves); introduction of Ligfol to VL-infected young animals from newborn to 15-18 months. weakly enhances the immune status, but improves the clinical condition of animals; immunotherapy of VL-infected heifers with Immunofan and Biferon-B helps to reduce immune tension caused by a viral infection and contributes to an increase in natural resistance; Immunofan and Biferon-B immunomodulators in order to improve the immune status and normalize the clinical condition, it is advisable to use VL-infected calves from newborn to 6 months and heifers (18 months).