The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats

International Journal of Fauna and Biological Studies Pub Date : 2022-12-13 DOI:10.47941/ijbs.1148

V. Victor, Ajie, P.C Ajie, Reuben, E Reuben, O. E. O. Okpara, George, B.O George, Fred, B.B Fred, O. O. Otto

{"title":"The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats","authors":"V. Victor, Ajie, P.C Ajie, Reuben, E Reuben, O. E. O. Okpara, George, B.O George, Fred, B.B Fred, O. O. Otto","doi":"10.47941/ijbs.1148","DOIUrl":null,"url":null,"abstract":"Purpose: The kidneys serve as the excretory organ of the body. The assessment of serum creatinine, urea, and electrolytes (Na+, K+, HCO3-, Cl-) are crucial and sensitive biochemical markers that are usually involved in the diagnosis of renal impairments (Agbasi et al. 2010; Tietz, 2008; Yakubu et al. 2003). \nMethodology: Thirty-six animals were grouped into 6, with 6 rats in each group. The animals were housed at room temperature in metal cages. Animals in each group had access to clean water and commercial standard rodent pellets. Group 1 (control group) received distilled water, Groups 2-6 were treated orally with low, middle, and high doses of ethanolic extract of Justicia secunda leaves daily for 42 days. \nFindings: A significant increase in the level of urea concentration was observed compared to the control. From the present study, Na+, K+, Cl-, and HCO3 increased significantly in the moderate and high dose groups. \nUnique contribution to theory, policy and practice: In conclusion, this study indicates that ethanolic extract of Justicia secunda increased the serum level of urea, creatinine, and electrolytes.","PeriodicalId":13993,"journal":{"name":"International Journal of Fauna and Biological Studies","volume":"23 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Fauna and Biological Studies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47941/ijbs.1148","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The kidneys serve as the excretory organ of the body. The assessment of serum creatinine, urea, and electrolytes (Na+, K+, HCO3-, Cl-) are crucial and sensitive biochemical markers that are usually involved in the diagnosis of renal impairments (Agbasi et al. 2010; Tietz, 2008; Yakubu et al. 2003). Methodology: Thirty-six animals were grouped into 6, with 6 rats in each group. The animals were housed at room temperature in metal cages. Animals in each group had access to clean water and commercial standard rodent pellets. Group 1 (control group) received distilled water, Groups 2-6 were treated orally with low, middle, and high doses of ethanolic extract of Justicia secunda leaves daily for 42 days. Findings: A significant increase in the level of urea concentration was observed compared to the control. From the present study, Na+, K+, Cl-, and HCO3 increased significantly in the moderate and high dose groups. Unique contribution to theory, policy and practice: In conclusion, this study indicates that ethanolic extract of Justicia secunda increased the serum level of urea, creatinine, and electrolytes.

查看原文本刊更多论文

天麻醇提物对雌性Wistar大鼠肾功能的影响

目的:肾脏是人体的排泄器官。血清肌酐、尿素和电解质(Na+、K+、HCO3-、Cl-)的评估是至关重要且敏感的生化指标，通常用于肾损害的诊断(Agbasi et al. 2010;Tietz, 2008;Yakubu et al. 2003)。方法:36只动物每组6只，每组6只。这些动物被关在室温下的金属笼子里。每组的动物都可以获得清洁的水和商业标准的啮齿动物颗粒。第1组(对照组)给予蒸馏水，第2 ~ 6组每天分别口服低、中、高剂量刺麻叶乙醇提取物，连续42 d。结果:与对照组相比，尿素浓度水平显著增加。从本研究来看，中、高剂量组Na+、K+、Cl-、HCO3均显著升高。在理论、政策和实践方面的独特贡献:本研究表明，天竺葵醇提物可提高血清尿素、肌酐和电解质水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Fauna and Biological Studies

自引率

0.00%

发文量