Identification and antibiotic susceptibility profile of methicillin and erythromycin resistant genes in clinical and environmental strains of Staphylococcus aureus in Minna Nigeria

Bayero Journal of Pure and Applied Sciences Pub Date : 2022-12-09 DOI:10.4314/bajopas.v15i1.28

G. Mamman, C.N. Angulu, G. Musa, S. Angulu

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Abstract

Staphylococcus aureus that is resistant to the antibiotic methicillin (MRSA) is a growing global health threat. The disc diffusion method was used to investigate the antibiotic susceptibility profile of Staphylococcus aureus. From clinical and environmental samples, Staphylococcus aureus was detected in 21.9% (73/360) of the cases. Staphylococcus aureus predominance in environmental samples was 24%, compared to 20.5 in clinical samples. The prevalence of Staphylococcus aureus was highest among people aged 18 to 49 (74%) and lowest among those aged 0 to 17 (42%) and 50 to 70 (4%). Staphylococcus aureus was more common in females (22.4%), compared to males (20%). Staphylococcus aureus showed 88.60%, 45.60%, 34.20%, 21.50%, 18.90%, 11.40%, 8.90%, 6.30%, and 5.10%, respectively, resistance to Oxacillin, Cefoxitin, Ampicillin, Vancomycin, Erythromycin, Norfloxacin, Rifampicin, and Gentamycin. All 79 of the Staphylococcus aureus isolates were 100% responsive to septrin and levofloxacin. The isolates were used to molecularly identify the genes for methicillin (mecA) and erythromycin (ermA and ermC). The clinical and environmental samples revealed a comparatively high frequency of Staphylococcus aureus.

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尼日利亚米纳金黄色葡萄球菌临床和环境菌株甲氧西林和红霉素耐药基因的鉴定和药敏分析

对抗生素甲氧西林(MRSA)具有耐药性的金黄色葡萄球菌是一个日益严重的全球健康威胁。采用圆盘扩散法对金黄色葡萄球菌的药敏谱进行了研究。临床及环境标本中检出金黄色葡萄球菌的占21.9%(73/360)。金黄色葡萄球菌在环境样品中的优势为24%，而在临床样品中的优势为20.5%。金黄色葡萄球菌的患病率在18至49岁的人群中最高(74%)，在0至17岁(42%)和50至70岁(4%)的人群中最低。金黄色葡萄球菌在女性(22.4%)中较男性(20%)更为常见。金黄色葡萄球菌对奥西林、头孢西丁、氨苄西林、万古霉素、红霉素、诺氟沙星、利福平和庆大霉素的耐药率分别为88.60%、45.60%、34.20%、21.50%、18.90%、11.40%、8.90%、6.30%和5.10%。所有79株金黄色葡萄球菌对septrin和左氧氟沙星均有100%的反应。利用分离物对甲氧西林(mecA)和红霉素(ermA和ermC)基因进行分子鉴定。临床和环境样本显示金黄色葡萄球菌的频率较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bayero Journal of Pure and Applied Sciences

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