Dexlansoprazole MR in the Management of Gastroesophageal Reflux Disease

K. Olsen, Margaret L. Hitzeman
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引用次数: 6

Abstract

Dexlansoprazole MR, an enantiomer of lansoprazole, is a unique proton pump inhibitor with a duel release mechanism. This release mechanism produces two distinct peak concentrations that result in a prolonged mean residence time with increased duration of plasma concentrations and a greater percent time the pH is maintained above 4. The prolonged residence time allows dexlansoprazole MR to be administered throughout the day without regards to meals or the timing before a meal. In two trials of patients with erosive esophagitis, dexlansoprazole MR 60 mg and 90 mg demonstrated comparable healing rates to lansoprazole 30 mg. In patients with healed EE, dexlansoprazole MR 30 mg (75%) and 60 mg (83%) were superior to placebo (27%; p < 0.0025) in maintenance of healing. Dexlansoprazole MR 30 mg and 60 mg had a greater percentage of heartburn-free days (91%–96%) and heartburn-free nights (96%–99%) than placebo (29%–72%) over the 6-month maintenance trial. Dexlansorpazole MR appears to be well tolerated with the safety profile being similar to lansoprazole with gastrointestinal adverse events being the most common. Dexlansoprazole MR provides a new treatment option for gastroesophageal reflux disease due to the flexible dosing, the unique release mechanisms and prologned pharmacodynamic effect.
右兰索拉唑MR治疗胃食管反流病
右兰索拉唑MR是兰索拉唑的对映体,是一种独特的质子泵抑制剂,具有双重释放机制。这种释放机制产生两个不同的峰值浓度,导致平均停留时间延长,血浆浓度持续时间增加,pH值维持在4以上的时间增加。延长的停留时间允许右兰索拉唑MR全天使用,而不考虑用餐或饭前时间。在两项糜烂性食管炎患者的试验中,60 mg和90 mg右兰索拉唑MR的治愈率与30 mg兰索拉唑相当。在愈合的EE患者中,右兰索拉唑MR 30mg(75%)和60mg(83%)优于安慰剂(27%;P < 0.0025)。在为期6个月的维持试验中,右兰索拉唑mr30mg和60mg的无烧心天数(91%-96%)和无烧心天数(96%-99%)比安慰剂(29%-72%)的比例更高。右兰索拉唑MR耐受性良好,其安全性与兰索拉唑相似,胃肠道不良事件最为常见。右兰索拉唑MR以其灵活的剂量、独特的释放机制和长效的药效学效应,为胃食管反流病的治疗提供了新的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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