Fatty acid profile of the liver lipids under acute fungicide action and intake of a biologically active preparation in rats

The Ukrainian Biochemical Journal Pub Date : 2022-11-10 DOI:10.15407/ubj94.04.047

S. Khyzhnyak, S. Midyk, A. O. Velinska, O. Arnauta, L. Н. Kalachniuk

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Abstract

The widespread use of fungicides in agriculture leads to a negative consequences for both humans and the environment. The acute effect of fungicides containing tebuconazole alone or in combination with triadimefon on fatty acid (FAs) composition of the total lipids in the liver of rats was studied. FAs content was analyzed by gas chromatography with the use of flame ionization detector. The results obtained indicate that the acute effect of triazole fungicides one-time oral administration to rats is characterized by toxic reactions and is accompanied by the total liver lipids FAs profile redistribution, similar for the studied fungicides. In particular, the reduction in the total content of monounsaturated FAs (by 26% – 37%) and in the ω3/ω6 ratio was observed. It was demonstrated that the subsequent two-week introduction of the preparation based on Milk thistle seeds oil extract had a positive effect and improved the FAs profile of lipids in dynamics after fungicide intake. Keywords: fatty acids, fungicides, Milk thistle seeds extract, rat liver lipids, triazoles

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急性杀菌剂作用下大鼠肝脏脂质脂肪酸谱及生物活性制剂的摄入

杀菌剂在农业中的广泛使用对人类和环境都造成了负面影响。研究了含戊康唑的杀菌剂单用或联用三二美酮对大鼠肝脏总脂质脂肪酸组成的急性影响。采用气相色谱法和火焰电离检测器分析FAs含量。结果表明，三唑类杀菌剂一次性口服对大鼠的急性作用表现为毒性反应，并伴有肝总脂质FAs谱的重分布，与所研究的杀菌剂相似。特别是，单不饱和脂肪酸的总含量降低了26% - 37%，ω3/ω6比值也降低了。结果表明，随后两周引入乳蓟籽油提取物的制剂具有积极作用，并在摄入杀菌剂后动态改善了脂质FAs谱。关键词:脂肪酸，杀菌剂，水飞蓟籽提取物，大鼠肝脂，三唑

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The Ukrainian Biochemical Journal

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