008 The time‐course of TL‐01 UVB erythema

I. Man, R. Dawe, J. Ferguson, S. Ibbotson
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引用次数: 2

Abstract

We examined the characteristics of TL-01 UVB erythema and determined the optimal starting dose prior to TL-01 phototherapy, Twenty-eight subjects were recruited. Eight test sites on each subject's back were irradiated with a TL-01 dose series (50-550 mJ/cm2). Erythema was recorded visually and with a reflectance device at 4, 8, 12, 24, 48 and 72 h in 19 subjects and at 12, 15, 18, 21 and 24 h in nine subjects. Dose-response curves were constructed and the D0.025 (equivalent to the visual minimal erythema dose [MED]) and the maximum slope determined. Erythema was evident at 4 h in the 19 subjects tested. The lowest median MED occurred at 12 h (170 mJ/cm2) and this was significantly lower that at 24 h (median 200 mJ/cm2; P = 0.019). the majority of subjects were at maximal erythema at 12 h (22/28) and 15 h (8/9). MED reading at 24 h (MED24 h) would miss peak erythema in 15/28 subjects. If, as is commonly practiced, 70% of the MED24 h was given, 10/28 subjects would have received a first treatment dose that would be equal to or exceed the lowest MED. If 50% of the MED24 h was given, only 2/28 would develop erythema (P = 0.0078, 95% Cl [10-46.5%]). From the dose-response data, D0.025 at 12 h was significantly lower than at 24 h (P = 0.0019). The slope of the erythemal dose-response curve remained constant from 8 to 48 h. Maximal TL-01 UVB erythema occurs at 12 h. Our data suggest that the optimal first TL-01 treatment dose is 50% of the MED24 h.
008 . tl01 UVB红斑的病程
我们检查了TL-01 UVB红斑的特征,并确定了TL-01光疗前的最佳起始剂量,招募了28名受试者。以TL-01剂量系列(50-550 mJ/cm2)照射每位受试者背部的8个试验点。19例受试者在4、8、12、24、48和72 h, 9例受试者在12、15、18、21和24 h用反射仪记录红斑。构建剂量-反应曲线,确定D0.025(相当于视觉最小红斑剂量[MED])和最大斜率。19名受试者在4小时出现明显的红斑。最低中位MED发生在12 h (170 mJ/cm2),显著低于24 h(中位200 mJ/cm2;p = 0.019)。大多数受试者在12小时(22/28)和15小时(8/9)出现最大红斑。24 h MED读数(MED24 h)将错过15/28受试者的峰值红斑。如果按照通常的做法,给予70%的MED24小时,10/28的受试者将接受等于或超过最低MED的首次治疗剂量。如果给予50%的MED24小时,只有2/28的受试者会发生红斑(P = 0.0078, 95% Cl[10-46.5%])。从剂量反应数据来看,12 h时D0.025显著低于24 h时(P = 0.0019)。从8到48小时,红斑剂量-反应曲线的斜率保持不变。最大的TL-01 UVB红斑发生在12小时。我们的数据表明,最佳的首次TL-01治疗剂量是MED24小时的50%。
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