Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

International Journal of Hepatology Pub Date : 2016-12-08 DOI:10.1155/2016/5160754

M. Kumar, Akanksha Singh, A. Jaryal, P. Ranjan, K. Deepak, Sanjay Sharma, R. Lakshmy, R. Pandey, N. Vikram

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引用次数: 20

Abstract

Aim. The present study was designed to evaluate the heart rate variability (HRV) in nonalcoholic fatty liver disease (NAFLD) and to assess the effect of grade of NAFLD and diabetic status on HRV. Methods. This cross-sectional study included 75 subjects (25 NAFLD without diabetes, 25 NAFLD with diabetes, and 25 controls). Measurements included anthropometry, body composition analysis, estimation of plasma glucose, serum lipids, hsCRP, and serum insulin. HRV analysis was performed in both time and frequency domains. Results. The time and frequency domain indices of overall variability (SDNN, total power) were significantly lower in NAFLD with diabetes as compared to the controls. However, the LF : HF ratio did not differ among the three groups. The variables related to obesity, lipid profile, and glucose metabolism were also higher in NAFLD with diabetes and those with Grade II NAFLD without diabetes, as compared to controls. Multivariate stepwise regression analysis showed a negative correlation between HRV and total cholesterol and fat percentage. Conclusion. The grade of NAFLD as well as diabetic status contributes to the decrease in the cardiovascular autonomic function, with diabetic status rather than grade of NAFLD playing a critical role. Serum lipids and adiposity may also contribute to cardiac autonomic dysfunction.

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非酒精性脂肪肝患者的心血管自主神经功能障碍

的目标。本研究旨在评估非酒精性脂肪性肝病(NAFLD)的心率变异性(HRV)，并评估NAFLD分级和糖尿病状态对HRV的影响。方法。这项横断面研究包括75名受试者(25名非糖尿病NAFLD, 25名合并糖尿病NAFLD和25名对照)。测量包括人体测量、身体成分分析、血浆葡萄糖、血脂、hsCRP和血清胰岛素的估计。在时域和频域进行HRV分析。结果。与对照组相比，NAFLD合并糖尿病患者的总变异性时域和频域指数(SDNN，总功率)显著降低。然而，三组之间的LF: HF比值没有差异。与对照组相比，伴有糖尿病的NAFLD和没有糖尿病的II级NAFLD患者的肥胖、血脂和糖代谢相关变量也更高。多因素逐步回归分析显示HRV与总胆固醇、脂肪率呈负相关。结论。NAFLD的级别和糖尿病状态都有助于心血管自主功能的下降，其中糖尿病状态而非NAFLD的级别起关键作用。血脂和肥胖也可能导致心脏自主神经功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.