Malignant Transformation of Oral Lichen Planus—An Umbrella Study of Systematic Reviews

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Pub Date : 2023-07-03 DOI:10.3390/oral3030024

S. Warnakulasuriya, P. Ramos-García, M. Gonzalez-Moles

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引用次数: 2

Abstract

Oral lichen planus (OLP) is classified as a potentially malignant disorder. Systematic reviews collating longitudinal observation studies provide evidence of the rate or proportion of malignant transformation. We conducted an umbrella study of published systematic reviews. An extensive English-language study search was carried out in several databases to identify relevant articles, providing systematic reviews on the malignant transformation of OLP. Data from eight systematic reviews published between 2014 and 2023 are presented. The reported proportions of malignant transformation ranged from 1.1% to 1.4%. A meta-analysis based on the 10 highest-quality studies yielded a higher proportion of malignant transformation (2.28%). We list some limitations found in several of these systematic reviews. Some studies reported an increased risk of malignancy in OLP lesions, demonstrating epithelial dysplasia. In view of the consistent evidence of the risk of oral malignancy, OLP patients should be monitored carefully to detect early cancer development.

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口腔扁平苔藓的恶性转化——系统综述的总括性研究

口腔扁平苔藓(OLP)被列为一种潜在的恶性疾病。系统评价整理纵向观察研究提供了恶性转化率或比例的证据。我们对已发表的系统综述进行了概括性研究。在几个数据库中进行了广泛的英语研究检索，以确定相关文章，对OLP的恶性转化进行了系统的回顾。本文介绍了2014年至2023年间发表的8篇系统综述的数据。报道的恶性转化比例从1.1%到1.4%不等。基于10项最高质量研究的荟萃分析显示，恶性转化的比例更高(2.28%)。我们列出了在这些系统综述中发现的一些局限性。一些研究报道了OLP病变中恶性肿瘤的风险增加，表现为上皮发育不良。鉴于有一致的证据表明口腔恶性肿瘤的风险，OLP患者应仔细监测，以发现早期癌症发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 医学-牙科与口腔外科

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审稿时长

1 months