The effects of propofol on normal and hypercholesterolemic isolated rabbit heart

General Pharmacology-the Vascular System Pub Date : 2000-08-01 DOI:10.1016/S0306-3623(01)00092-1

Sermin Öztekin , Sule Kalkan , Deniz Ozzeybek , Yesim Tuncok , Hulya Guven , Zahide Elar

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引用次数: 3

Abstract

The aim of the present study was to compare the effects of propofol on cardiac contractile force in normal and hypercholesterolemic isolated rabbit hearts. While one group was fed with standard chow pellets (150 g/day), the other group received cholesterol (1% w/w) in addition to the same amount of rabbit chow pellets during 1 month. Hearts from standard-fed rabbits were given intralipid solvent or 25, 50 and 100 μM propofol by infusion. Hypercholesterolemic rabbit hearts were administered 25, 50 and 100 μM propofol by infusion. All concentrations of propofol did not result in any significant change of the heart rates (HR) in two groups. Propofol (25, 50 and 100 μM) infusion induced a concentration- and time-dependent inhibition in left ventricular pressure (LVP) in standard chow diet group (P<.05, .05 and .05, respectively). In hypercholesterolemic rabbit hearts, 25 and 50 μM propofol infusion developed a significant inhibition in LVP when compared with the standard chow diet group (P<.05 and .05, respectively). Propofol (100 μM) infusion developed a significant increase in LVP after 20 min in hypercholesterolemic rabbit hearts when compared with normal rabbit hearts (P<.05). Supratherapeutic concentration of propofol might have cardioprotective effect on hypercholesterolemic rabbit hearts.

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异丙酚对正常和高胆固醇血症兔离体心脏的影响

本研究的目的是比较异丙酚对正常和高胆固醇血症离体兔心脏收缩力的影响。其中一组饲喂标准饲料颗粒(150 g/d)，另一组在等量兔饲料颗粒的基础上饲喂胆固醇(1% w/w)，为期1个月。用脂质溶剂或25、50、100 μM异丙酚输注标准饲养家兔心脏。分别给高胆固醇血症家兔心脏输注25、50和100 μM异丙酚。在两组中，所有浓度的异丙酚均未引起心率(HR)的显著变化。异丙酚(25、50和100 μM)输注对标准鼠粮组左心室压(LVP)有浓度依赖性和时间依赖性抑制作用(P<分别为0.05、0.05和0.05)。在高胆固醇血症的兔子心脏中，与标准饲料组相比，25和50 μM异丙酚输注对LVP有显著的抑制作用(P<分别为0.05和0.05)。与正常兔心脏相比，异丙酚(100 μM)在高胆固醇血症兔心脏20分钟后显著增加LVP (P< 0.05)。异丙酚超治疗浓度对高胆固醇血症家兔心脏可能有保护作用。

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General Pharmacology-the Vascular System

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