Congenital malformations in offspring of Vietnamese women in California, 1985-97.

Teratology Pub Date : 2002-03-01 DOI:10.1002/TERA.10020

G. Shaw, S. Carmichael, V. Nelson

{"title":"Congenital malformations in offspring of Vietnamese women in California, 1985-97.","authors":"G. Shaw, S. Carmichael, V. Nelson","doi":"10.1002/TERA.10020","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nLittle is known about reproductive outcome risks for Vietnamese women delivering infants and fetuses in the U.S.\n\n\nMETHODS\nUsing data from a large population-based registry, we explored risks of selected congenital malformation phenotypes in offspring of Vietnamese women in California. Data were derived from the California Birth Defects Monitoring Program, a population-based active surveillance system for collecting information on infants and fetuses with congenital malformations using multiple source ascertainment. Approximately 3.4 million births (liveborn and stillborn) occurred during the ascertainment period, 1985-97. Information on maternal race/ethnic background was obtained from California birth certificate and fetal death files. Vietnamese women delivered 45,453 births and 1,257,853 births were delivered to non-Hispanic white women.\n\n\nRESULTS\nThe overall prevalence of structural congenital malformations was 1.92 among Vietnamese and 2.63 among non-Hispanic whites per 100 births and fetal deaths. Grouping by 20 3-digit malformation codes of the International Classification of Diseases-Ninth Revision revealed relative risks of 0.8 or less for spina bifida, eye, upper alimentary, genital, urinary, musculoskeletal, \"other\" limb, and \"other\" musculoskeletal anomalies, and relative risks of 1.3 or more for anencephaly and chromosomal anomalies. Grouping by the more specific 4-digit malformation codes revealed 50, among 178, malformation groupings with associated relative risks of >or=1.3 or <or=0.8. Seventeen relative risk estimates suggested elevated risks for Vietnamese births, and 33 estimates suggested lowered risks for Vietnamese, relative to non-Hispanic white births. Simultaneous adjustment for maternal age, plurality, and child sex, did not substantially alter observed risks.\n\n\nCONCLUSIONS\nThese data contribute to a relatively sparse literature about an important subgroup of the U.S. population, but can not elucidate whether increased or decreased risks among Vietnamese are related to potential underlying genetic susceptibilities, to cultural, social, or political differences that could modify exposures, or to the many potential combinations between susceptibilities and exposures.","PeriodicalId":22211,"journal":{"name":"Teratology","volume":"14 1","pages":"121-4"},"PeriodicalIF":0.0000,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Teratology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/TERA.10020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 15

Abstract

BACKGROUND Little is known about reproductive outcome risks for Vietnamese women delivering infants and fetuses in the U.S. METHODS Using data from a large population-based registry, we explored risks of selected congenital malformation phenotypes in offspring of Vietnamese women in California. Data were derived from the California Birth Defects Monitoring Program, a population-based active surveillance system for collecting information on infants and fetuses with congenital malformations using multiple source ascertainment. Approximately 3.4 million births (liveborn and stillborn) occurred during the ascertainment period, 1985-97. Information on maternal race/ethnic background was obtained from California birth certificate and fetal death files. Vietnamese women delivered 45,453 births and 1,257,853 births were delivered to non-Hispanic white women. RESULTS The overall prevalence of structural congenital malformations was 1.92 among Vietnamese and 2.63 among non-Hispanic whites per 100 births and fetal deaths. Grouping by 20 3-digit malformation codes of the International Classification of Diseases-Ninth Revision revealed relative risks of 0.8 or less for spina bifida, eye, upper alimentary, genital, urinary, musculoskeletal, "other" limb, and "other" musculoskeletal anomalies, and relative risks of 1.3 or more for anencephaly and chromosomal anomalies. Grouping by the more specific 4-digit malformation codes revealed 50, among 178, malformation groupings with associated relative risks of >or=1.3 or

查看原文本刊更多论文

加利福尼亚越南妇女后代的先天性畸形，1985- 1997。

背景:在美国，越南妇女分娩婴儿和胎儿的生殖结局风险知之甚少。方法:利用基于大量人口的登记数据，我们探讨了加利福尼亚越南妇女后代中选定的先天性畸形表型的风险。数据来源于加州出生缺陷监测项目，这是一个基于人群的主动监测系统，用于收集先天性畸形婴儿和胎儿的信息，采用多种来源确定。在1985年至1997年的确定期间，大约发生了340万例分娩(活产和死产)。从加州出生证明和胎儿死亡档案中获得了关于母亲种族/民族背景的信息。越南妇女生育了45453个孩子，非西班牙裔白人妇女生育了1257853个孩子。结果越南裔和非西班牙裔白人的先天性畸形总患病率分别为每100例出生和死胎1.92例和2.63例。根据《国际疾病分类-第九版》的20个3位畸形编码分组，脊柱裂、眼、上消化道、生殖器、泌尿、肌肉骨骼、“其他”肢体和“其他”肌肉骨骼异常的相对危险度为0.8或更低，无脑畸形和染色体异常的相对危险度为1.3或更高。根据更具体的4位畸形编码分组，178个畸形组中有50个畸形组的相关相对风险为>or=1.3或

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Teratology

自引率

0.00%

发文量

京公网安备 11010802042870号

Book学术文献互助群
群号：481959085