Tenecteplase for Thrombolysis in Acute Ischemic Stroke and Its Outcome—An Indian Experience

Madhavi Karri, Balakrishnan Ramasamy
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引用次数: 1

Abstract

Background: Stroke has been a growing concern with increasing morbidity and mortality worldwide. Tenecteplase has been approved in India as a newer thrombolytic, in acute ischemic stroke, since 2016. Very few studies have been reported to know the efficacy of Tenecteplase in AIS compared to alteplase. Aim: This study was done to understand the efficacy and related complications of Tenecteplase in AIS. Methods: In this prospective study, we took 112 people with AIS who received Tenecteplase, admitted between August 2018 and August 2020. After obtaining ethical approval, we tabulated patients’ data and did the statistical analysis using an unpaired t test, Analysis of Variance, and chi-square test. A P value of <.05 using a 2-tailed test was considered significant for all statistical analyses. Results: Out of 112 patients, 67.9% were male and 32.1% were female, with a mean age of 60.7 years. We classified stroke by using the TOAST classification. About 62.5% are classified as large atherosclerotic type, 14.3% cardioembolic, and 17.0% lacunar strokes. A total of 82.1% had a middle cerebral artery region stroke. The mean door to needle time was 76.7 min with a standard deviation of 33.3. The primary outcome was met in 47.3%, and the secondary result was achieved in 59.8%. Intracerebral hematoma was the most commonly observed complication. Mortality accounted for 9.8% of the total population. Conclusions: Tenecteplase is the newer thrombolytic agent with good efficacy. More studies are needed globally to understand regional differences and effectiveness.
替奈普酶用于急性缺血性脑卒中溶栓及其疗效——印度经验
背景:脑卒中的发病率和死亡率在世界范围内日益增加。自2016年以来,Tenecteplase已在印度被批准作为急性缺血性卒中的新型溶栓药物。与阿替普酶相比,很少有研究报道了替奈普酶对AIS的疗效。目的:了解替奈普酶治疗AIS的疗效及相关并发症。方法:在这项前瞻性研究中,我们选取了2018年8月至2020年8月期间入院的112名接受Tenecteplase治疗的AIS患者。在获得伦理批准后,我们将患者数据制成表格,并使用非配对t检验、方差分析和卡方检验进行统计分析。P值<。使用双尾检验的0.05在所有统计分析中被认为是显著的。结果:112例患者中男性占67.9%,女性占32.1%,平均年龄60.7岁。我们使用TOAST分类对中风进行分类。约62.5%为大动脉粥样硬化型,14.3%为心栓型,17.0%为腔隙性卒中。脑中动脉区卒中发生率为82.1%。门到针的平均时间为76.7 min,标准差为33.3。主要结局达到47.3%,次要结局达到59.8%。脑内血肿是最常见的并发症。死亡率占总人口的9.8%。结论:替奈普酶是一种疗效良好的新型溶栓药物。需要在全球范围内进行更多的研究,以了解区域差异和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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