Lack of Association between Seropositivity of Vasculopathy-Related Viruses and Moyamoya Disease.

Q2 Business, Management and Accounting

Journal of Business Strategy Pub Date : 2022-07-01 Epub Date: 2022-04-29 DOI:10.1016/j.jstrokecerebrovasdis.2022.106509

Yasuhisa Nakamura, Yohei Mineharu, Takahiko Kamata, Takeshi Funaki, Susumu Miyamoto, Akio Koizumi, Kouji H Harada

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Abstract

Objectives: Although the association between genetic factors, such as RNF213 mutations, and moyamoya disease (MMD) has been well investigated, environmental factors are largely undetermined. Thus, we aimed to examine whether viral infection increases the risk of MMD.

Materials and methods: To eliminate the effect of presence or absence of the RNF213 p.R4810K mutation, the entire study population was positive for this mutation. We collected whole blood from 111 patients with MMD (45 familial and 66 sporadic cases) and 67 healthy volunteers, and we measured the immunoglobulin G titer of 11 viruses (cytomegalovirus, varicella-zoster virus, measles virus, rubella virus, herpes simplex virus, mumps virus, Epstein-Barr virus, human parvovirus B19, human herpesvirus 6 [HHV6], human herpesvirus 8, and John Cunningham virus) that were presumed to be associated with vasculopathy using the enzyme-linked immunosorbent assay. Positivity for past viral infection was determined by cut-off values obtained from previous reports and the manufacturer's instructions, and the positive rate was compared between cases and age- and sex-matched controls. We performed familial case-specific and sporadic case-specific analyses, as well as a case-control analysis.

Results: There was no significant difference in the positive rate between the case group and the control group in any of the analyses. A significant difference was only observed in the combined case-control analysis for HHV6 (p = 0.046), but the viral antibody-positive rate in control individuals was higher than in MMD cases.

Conclusions: Our cross-sectional study suggest that the investigated 11 viruses including HHV6 are unlikely to have an impact on MMD development.

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血管病变相关病毒血清阳性与莫亚莫亚病之间缺乏关联性

研究目的尽管RNF213基因突变等遗传因素与莫亚莫亚氏病（MMD）之间的关系已得到充分研究，但环境因素在很大程度上尚未确定。因此，我们旨在研究病毒感染是否会增加罹患MMD的风险：为了排除是否存在 RNF213 p.R4810K 基因突变的影响，所有研究对象的该基因突变均为阳性。我们采集了 111 位 MMD 患者（45 位家族性病例和 66 位散发性病例）和 67 位健康志愿者的全血，并测量了 11 种病毒（巨细胞病毒、水痘-带状疱疹病毒、麻疹病毒、风疹病毒、单纯疱疹病毒、腮腺炎病毒、疱疹病毒）的免疫球蛋白 G 滴度、我们使用酶联免疫吸附试验检测了 11 种推测与血管病变相关的病毒（巨细胞病毒、水痘-带状疱疹病毒、麻疹病毒、风疹病毒、单纯疱疹病毒、腮腺炎病毒、爱泼斯坦-巴氏病毒、人类细小病毒 B19、人类疱疹病毒 6 [HHV6]、人类疱疹病毒 8 和约翰-坎宁安病毒）的免疫球蛋白 G 滴度。以往病毒感染的阳性率是根据以前的报告和生产商的说明得出的临界值确定的，并比较了病例与年龄和性别匹配的对照组之间的阳性率。我们进行了家族病例特异性分析、散发性病例特异性分析以及病例对照分析：结果：在所有分析中，病例组和对照组的阳性率均无明显差异。只有在 HHV6 的病例-对照综合分析中观察到明显差异（p = 0.046），但对照组的病毒抗体阳性率高于麻风病病例：我们的横断面研究表明，包括 HHV6 在内的 11 种被调查病毒不太可能对 MMD 的发病产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Business Strategy Business, Management and Accounting-Management Information Systems

CiteScore

4.50

自引率

0.00%

发文量

期刊介绍： The Journal of Business Strategy publishes articles with a practical focus designed to help readers develop successful business strategies. Articles should say something new or different and may propose a unique perspective. They should not offer prescriptions to CEOs on how to manage, but rather be directed toward middle and senior managers at companies of all sizes and types, as well as consultants and academics who want to think about their businesses in new ways. Coverage: As one of the few journals dedicated to business strategy, JBS defines strategy in the broadest sense and thus covers topics as diverse as marketing strategy, innovation, developments in the global economy, mergers & acquisition integration and human resources. We have a penchant for substantive, provocative and well-written articles. We also like to break the mould and include articles on topics readers are unlikely to find in other business publications.