Characterization and antioxidant activity of newly synthesized N1-(2-chlorophenyl)-N2-phenyl-1,2-hydrazinedicarbothioamide and its Cu(II), Zn(II), ZrO(II), Hg(II) and UO2(II) metal complexes

Abstract

Thiourea derivatives are well known class of organic compounds having diverse application in the field of medicine, agriculture, coordination, and analytical chemistry. This study reports novel N1-(2-chlorophenyl)-N2-phenyl-1,2-hydrazinedicarbothioamide and its Mn (II),Co(II), Ni(II),Cu(II), metal complexes. These synthesized compounds were characterized by H1NMR, UV-Vis, IR spectroscopy and elemental (CHN/S) analysis. Moreover, antioxidant activity was screened for synthesized compounds. All the compounds showed significant antioxidant potential with IC50 values ranges from 23.81± 1.57µM - 58.32± 1.23µM. It was revealed that synthesized compounds displayed better antioxidant activity with IC50 values between 127.10-271.41 µM to256.42 ± 0.34 µM. The ligand (IC50 =33.41 ± 1.32µM)as well as metal complex Cu(L)2 (IC50 = 28.10± 1.05µM ), Zn(L)2 (IC50 = 24.53± 1.12µM), ZrO(L)2 (IC50 = 58.32± 1.23µM), Hg(L)2 (IC50 = 23.81± 1.57µM ), UO2(L)2 (IC50 =52.14± 1.45µM) showed far better activity than the standard (IC50 = 44.7± 1.21). Among these metal complexes, Hg complex (IC50 = 23.81 ± 1.57) showed highest antioxidant activity, while Zn complex (IC50= 24.53 ± 1.12), Cu complex (28.10 ± 1.05) and Co complex (IC50= 29.76 ± 1.21), The metal complexes UO2(L)2, ZrO(L)2 showed moderate anti-oxidant activity. These compounds were found be less active than other metal complexes as well as standard. The antioxidant activity pattern of these compounds is Hg(L)2 > Zn(L)2 > Cu(L)2 > UO2(L) > ZrO(L)2. These metal complexes showed remarkable antioxidant activity which may find their importance in avoiding or reducing the development of both heart disease and some forms of cancer.