Vinca ( Catharanthus roseus ) Extracts Attenuate Alloxan-Induced Hyperglycemia and Oxidative Stress in Rats

American Journal of Food Science and Technology Pub Date : 2021-11-05 DOI:10.12691/AJFST-9-4-8

Y. Elhassaneen, Sherif Ragab, A. A. El-Rahman, S. Arafa

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引用次数: 4

Abstract

The present study was carried out to investigate the effectiveness of Catharanthus roseus extracts in modulating the hyperglycemia and oxidative stress (OS) of alloxan-induced diabetic rats. Treatment of rats with alloxan caused a significant (p≤0.05) increased in serum glucose concentration by the ratio of 273.61% compared to normal control group. Supplementation of the rat diets with 300, 400 and 500 mg/kg of ethanolic Catharanthus roseus stems extract (CRSE) and ethanolic Catharanthus roseus leaves extract (CRLE) decreased this value which recorded 184.72, 113.47 and 76.39%, and 139.86, 112.91 and 57.36%, respectively. The rate of attenuation exhibited a dose dependent increase with both extracts consumption. Also, CRLE is more effective in the attenuation process than CRSE. The same behavior was recorded for the biomarkers of OS levels in serum i.e. malonaldehyde (MDA). In contrary, significant (P≤0.05) improving in different antioxidant defense systems in both serum (glutathione fractions, GSH), and RBC's (antioxidant enzymes including glutathione peroxidase, GSH-Px, glutathione reductase, GSH-Rd and catalases, CAT) were recorded. Such biochemical changes observed in the present study were confirmed by the histopathological examination results. In conclusion, Catharanthus roseus possess a variety of beneficial activities and have the potential to impart therapeutic effect holistically in complicated disorders like diabetes and its complications.

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长春花提取物减轻四氧嘧啶诱导的高血糖和氧化应激大鼠

本研究旨在探讨花楸提取物对四氧嘧啶诱导的糖尿病大鼠高血糖和氧化应激的调节作用。四氧嘧啶组大鼠血清葡萄糖浓度较正常对照组显著升高(p≤0.05)，升高幅度为273.61%。在饲粮中添加300、400和500 mg/kg的乙醇花楸茎提取物(CRSE)和乙醇花楸叶提取物(CRLE)使该值降低，分别为184.72、113.47和76.39%，139.86、112.91和57.36%。随着两种提取物的消耗，衰减率呈剂量依赖性增加。在衰减过程中，CRLE比CRSE更有效。血清中OS水平的生物标志物(即丙二醛(MDA))也记录了相同的行为。相反，血清(谷胱甘肽组分，GSH)和红细胞(抗氧化酶，谷胱甘肽过氧化物酶，谷胱甘肽- px，谷胱甘肽还原酶，谷胱甘肽- rd和过氧化氢酶，CAT)的不同抗氧化防御系统均有显著(P≤0.05)改善。本研究观察到的这些生化变化为组织病理学检查结果所证实。综上所述，长春花具有多种有益活性，对糖尿病及其并发症等复杂疾病具有整体治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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American Journal of Food Science and Technology

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