RuCl3 · nH2O as Catalyst for Diastereoselective Direct Aldol Reaction: An Efficient Route to Hormone Steroid Derivatives

Abstract

RuIII-catalyzed regio- and diastereoselective direct aldol reaction of progesterone with aromatic aldehydes has been developed in good yields (58–78%). Advantages of this method include catalytic efficiency, short reaction times, and ease of operation and workup.