J. Bolodeoku., S. Bains, Vivek Chand, R. Bacon, P. Weir, V. Miles, F. Chinegwundoh
{"title":"An Evaluation of the Point-of-Care Test i-CHROMA Prostate-Specific Antigen Method for Screening in the Community","authors":"J. Bolodeoku., S. Bains, Vivek Chand, R. Bacon, P. Weir, V. Miles, F. Chinegwundoh","doi":"10.1097/POC.0000000000000131","DOIUrl":null,"url":null,"abstract":"Background This study evaluated and compared the performance of the i-CHROMA point-of-care testing (POCT) method for the quantification of prostate-specific antigen (PSA) against a traditional laboratory PSA method (Abbott Architect assay). Materials and Method Blood samples (venous [143] serum [143]) and finger prick (55) were collected from volunteers at a PSA screening campaign. Both venous and finger-prick samples were analyzed using the i-CHROMA PSA method and serum samples using the Abbott Architect method. Results were compared using linear regression and Red Amber Green analysis, a scoring system based on volunteer's age and PSA level. Red indicated a raised PSA, amber indicated a slightly raised PSA, and green indicated a normal PSA. Results The data showed that both the i-CHROMA PSA results using the venous samples (r2 = 0.9841) and the finger-prick samples (r2 = 0.90845) showed a good correlation when compared with the serum samples using the laboratory method. The Red Amber Green analysis showed the i-CHROMA' venous PSA method identified 15 reds, 13 ambers, and 115 greens compared with 9 reds, 8 ambers, and 126 greens identified by Abbot Architect method. The i-CHROMA finger-prick PSA method identified 3 reds, 3 ambers, and 49 greens compared with 3 reds, 1 ambers, and 51 greens identified by Abbot Architect method. Conclusions The i-CHROMA POCT PSA method showed good correlation with the Abbott Architect PSA method. Higher numbers of raised and abnormal PSA were identified by the i-CHROMA POCT PSA method due to the positive bias observed. The i-CHROMA POCT PSA method is a reliable method for total PSA within its limitations.","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"42 1","pages":"93–96"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Point of Care: The Journal of Near-Patient Testing & Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/POC.0000000000000131","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Background This study evaluated and compared the performance of the i-CHROMA point-of-care testing (POCT) method for the quantification of prostate-specific antigen (PSA) against a traditional laboratory PSA method (Abbott Architect assay). Materials and Method Blood samples (venous [143] serum [143]) and finger prick (55) were collected from volunteers at a PSA screening campaign. Both venous and finger-prick samples were analyzed using the i-CHROMA PSA method and serum samples using the Abbott Architect method. Results were compared using linear regression and Red Amber Green analysis, a scoring system based on volunteer's age and PSA level. Red indicated a raised PSA, amber indicated a slightly raised PSA, and green indicated a normal PSA. Results The data showed that both the i-CHROMA PSA results using the venous samples (r2 = 0.9841) and the finger-prick samples (r2 = 0.90845) showed a good correlation when compared with the serum samples using the laboratory method. The Red Amber Green analysis showed the i-CHROMA' venous PSA method identified 15 reds, 13 ambers, and 115 greens compared with 9 reds, 8 ambers, and 126 greens identified by Abbot Architect method. The i-CHROMA finger-prick PSA method identified 3 reds, 3 ambers, and 49 greens compared with 3 reds, 1 ambers, and 51 greens identified by Abbot Architect method. Conclusions The i-CHROMA POCT PSA method showed good correlation with the Abbott Architect PSA method. Higher numbers of raised and abnormal PSA were identified by the i-CHROMA POCT PSA method due to the positive bias observed. The i-CHROMA POCT PSA method is a reliable method for total PSA within its limitations.