Evaluation of Anti-Inflammatory Potential of Turmimax® an in vivo and in vitro Study

Abstract

: The main objective of this study was to investigate the in vivo and in vitro anti-inflammatory effects of the Turmimax ® bio-enhanced turmeric formulation. By comparing the relative fluorescence intensities of the interleukins IL-8 (Interleukin-8) and IL-12 (Interleukin-12) cytokines in stimulated murine Raw 264.7 macrophages, Turmimax ® was evaluated for its anti-inflammatory in vitro efficacy. Turmimax ® was administered orally in two doses, 100 and 200 mg/kg, to assess its in vivo anti-inflammatory potential in ear edema induced by croton oil in mice and paw edema induced by histamine in albino rats. Diclofenac sodium 10 mg/kg p.o. is the standard drug. The results demonstrated that Turmimax ® significantly and dose-dependently decreased the production of the inflammatory mediator’s interleukin-8 and IL-12. According to the current investigation results, Turmimax ® has shown strong anti-inflammatory effects.