Abnormal liver functional tests in children with congenital heart diseases – a cross-sectional study in the south-east of Iran

Q4 Medicine

Gastroenterologie a Hepatologie Pub Date : 2022-12-20 DOI:10.48095/ccgh2022485

I. Shahramian, A. Bazi, E. Akhlaghi, N. Noori, M. Tahani

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Abstract

Background: The clinical implication of abnormal liver functional tests (LFTs) is not well studied in children with congenital heart diseases (CHDs). We aimed to screen LFTs in children with CHDs. Methods: LFTs including liver enzymes (AST, ALT and ALP), as well as direct bilirubin (DB), total bilirubin and albumin were measured in 80 children with CHDs. Results: Ventricular septal defect (VSD), tetralogy of Fallot (TOF), atrial septa defect (ASD), congestive heart failure (CHF) and Patent ductus arteriosus (PDA) accounted for 45 (67.4%), 3 (3.8%), 25 (20%), 2 (2.5%) and 5 (6.2%) of our patients, respectively. Abnormally elevated ALT, AST, ALP, DB, TB and reduced total protein were identified in 3 (3.8%), 21 (26.2%), 6 (7.6%), 10 (12.5%), 7 (8.8%) and 43 (53.8%), respectively. There was no significant difference in LFTs among various CHDs except for AST (P = 0.04). The mean level of AST was significantly lower in children with VSD (31.4 ±10.7 IU/l) than those of TOF (48.3 ±22.8 IU/l, P = 0.03) and ASD (36.8 ±9.8 IU/l, P = 0.03). Conclusion: Considering the respectively high incidence of abnormal LFTs in children with CHDs, it is advisable to regularly monitor these tests to timely manage any progressions toward congestive or ischaemic hepatitis. Keywords congenital heart disease, ventricular septal defect, heart failure, ischaemic hepatitis

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先天性心脏病患儿肝功能检查异常——伊朗东南部的一项横断面研究

背景:先天性心脏病(CHDs)患儿肝功能检查异常(LFTs)的临床意义尚未得到很好的研究。我们的目标是筛查患有冠心病的儿童的LFTs。方法:测定80例冠心病患儿肝功能指数，包括肝酶(AST、ALT、ALP)及直接胆红素(DB)、总胆红素、白蛋白。结果:室间隔缺损(VSD)、法洛四联症(TOF)、房间隔缺损(ASD)、充血性心力衰竭(CHF)和动脉导管未闭(PDA)分别占45例(67.4%)、3例(3.8%)、25例(20%)、2例(2.5%)和5例(6.2%)。ALT、AST、ALP、DB、TB异常升高3例(3.8%)、21例(26.2%)、6例(7.6%)、10例(12.5%)、7例(8.8%)、43例(53.8%)。除AST外，不同冠心病患者LFTs差异无统计学意义(P = 0.04)。VSD患儿AST平均水平(31.4±10.7 IU/l)明显低于TOF患儿(48.3±22.8 IU/l, P = 0.03)和ASD患儿(36.8±9.8 IU/l, P = 0.03)。结论:考虑到冠心病患儿LFTs异常发生率分别较高，建议定期监测这些指标，及时管理任何进展为充血性或缺血性肝炎。先天性心脏病，室间隔缺损，心力衰竭，缺血性肝炎

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来源期刊

Gastroenterologie a Hepatologie Medicine-Gastroenterology

CiteScore

0.40

自引率

0.00%

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