ASSESSMENT OF HUMORAL IMMUNITY TO SARS-COV AMONG EMPLOYEES OF MEDICAL ORGANIZATIONS IN THE REPUBLIC OF TATARSTAN

Zh. G. Eremeeva, I. K. Minullin, E. Bogdanova, I. R. Iskandarov, Elvira Safina
{"title":"ASSESSMENT OF HUMORAL IMMUNITY TO SARS-COV AMONG EMPLOYEES OF MEDICAL ORGANIZATIONS IN THE REPUBLIC OF TATARSTAN","authors":"Zh. G. Eremeeva, I. K. Minullin, E. Bogdanova, I. R. Iskandarov, Elvira Safina","doi":"10.17816/eid133716","DOIUrl":null,"url":null,"abstract":"BACKGROUND: Since the beginning of the pandemic of a new coronavirus infection, preventive measures aimed at combating the spread of the pathogen, preventing the development of severe forms of infection and deaths have been improved. Despite the absence of a legally established generally accepted post-vaccination protective value of antibodies to coronavirus, the study of the presence of antibodies and the determination of their amount in the blood serum of the vaccinated population continues. \nAIM: The aim of the study is to present the results of the study of humoral immunity to SARS COV-2 in medical organizations. \nMATERIALS AND METHODS: The study involved employees of medical organizations of the State Autonomous Health Institution \"Republican Clinical Dermatovenerologic Dispensary of the Ministry of Health of the Republic of Tatarstan named after Professor A.G. Ge\" in Kazan and the State Autonomous Health Institution \"City Polyclinic No. 3\" in Naberezhnye Chelny in the number of 393 people who were vaccinated with the two-component vaccine GamCovidVac (Sputnik V), after which a sufficient amount of time has passed for the formation of an immune response: more than 21 days. The blood sera of 393 people (including 350 women) were examined for the determination of specific IgG to SARS-CoV-2 by enzyme immunoassay using the Vector-Best kit (Novosibirsk, Russia). Statistical analysis was carried out using the StatTech v. 2.8.8 (developer - Stattech LLC, Russia). \nRESULTS: \nThe median of the age of the subjects was 47 years (Q1 - Q3:39-59). The mean antibody titer level was 570 BAU/ml (Q1 Q3:128-1150). A correlation analysis of the relationship between titer levels and age at the time of vaccination was performed, according to the results of which a weak direct relationship was established, and when assessing the dependence of antibody titer levels on the duration of vaccination after the second component at the time of checking the titers, there was no connection. \nCONCLUSIONS: \nThe ongoing pandemic of a new coronavirus infection with the emergence of new forms of the disease caused by other strains of the virus, the improvement of prevention methods, requires constant monitoring of the epidemiological situation with the study of the effectiveness of vaccines, including at the cellular level.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of infectious diseases and epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17816/eid133716","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

BACKGROUND: Since the beginning of the pandemic of a new coronavirus infection, preventive measures aimed at combating the spread of the pathogen, preventing the development of severe forms of infection and deaths have been improved. Despite the absence of a legally established generally accepted post-vaccination protective value of antibodies to coronavirus, the study of the presence of antibodies and the determination of their amount in the blood serum of the vaccinated population continues. AIM: The aim of the study is to present the results of the study of humoral immunity to SARS COV-2 in medical organizations. MATERIALS AND METHODS: The study involved employees of medical organizations of the State Autonomous Health Institution "Republican Clinical Dermatovenerologic Dispensary of the Ministry of Health of the Republic of Tatarstan named after Professor A.G. Ge" in Kazan and the State Autonomous Health Institution "City Polyclinic No. 3" in Naberezhnye Chelny in the number of 393 people who were vaccinated with the two-component vaccine GamCovidVac (Sputnik V), after which a sufficient amount of time has passed for the formation of an immune response: more than 21 days. The blood sera of 393 people (including 350 women) were examined for the determination of specific IgG to SARS-CoV-2 by enzyme immunoassay using the Vector-Best kit (Novosibirsk, Russia). Statistical analysis was carried out using the StatTech v. 2.8.8 (developer - Stattech LLC, Russia). RESULTS: The median of the age of the subjects was 47 years (Q1 - Q3:39-59). The mean antibody titer level was 570 BAU/ml (Q1 Q3:128-1150). A correlation analysis of the relationship between titer levels and age at the time of vaccination was performed, according to the results of which a weak direct relationship was established, and when assessing the dependence of antibody titer levels on the duration of vaccination after the second component at the time of checking the titers, there was no connection. CONCLUSIONS: The ongoing pandemic of a new coronavirus infection with the emergence of new forms of the disease caused by other strains of the virus, the improvement of prevention methods, requires constant monitoring of the epidemiological situation with the study of the effectiveness of vaccines, including at the cellular level.
鞑靼斯坦共和国医疗机构雇员对sars冠状病毒体液免疫的评估
背景:自新型冠状病毒感染大流行开始以来,旨在遏制病原体传播、防止发生严重感染和死亡的预防措施得到了改进。尽管没有法律确定的、普遍接受的冠状病毒抗体接种后的保护价值,但对疫苗接种人群血清中抗体的存在和抗体数量的测定的研究仍在继续。目的:介绍医疗机构对SARS COV-2体液免疫的研究结果。材料和方法:这项研究涉及喀山国家自治卫生机构“鞑靼斯坦共和国卫生部共和国临床皮肤性疾病诊所”和纳别列日涅切尔尼国家自治卫生机构“第三城市综合诊所”的医疗机构的员工,共有393人接种了双组份疫苗GamCovidVac (Sputnik V)。在此之后,有足够的时间形成免疫反应:超过21天。使用Vector-Best试剂盒(俄罗斯新西伯利亚)对393人(包括350名妇女)的血清进行酶免疫测定,以确定对SARS-CoV-2的特异性IgG。统计分析使用StatTech v. 2.8.8(开发商- StatTech LLC, Russia)进行。结果:受试者年龄中位数为47岁(Q1 - Q3:39-59)。平均抗体滴度为570 BAU/ml (Q1 Q3:128-1150)。对抗体滴度水平与接种时年龄之间的关系进行了相关分析,结果显示存在微弱的直接关系,而在检测滴度时评估抗体滴度水平与第二组分后接种时间的依赖关系时,没有关联。结论:新型冠状病毒感染的持续大流行与其他病毒株引起的新形式疾病的出现,需要不断监测流行病学情况并研究疫苗的有效性,包括在细胞水平上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信