ANTI-INFLAMMATORY ACTIVITY OF STEM BARK DICHLOROMETHANE FRACTION Syzygium samarangense EXTRACT AS COX-2 INHIBITOR: A BIOINFORMATICS APPROACH

A. Sururi, M. Raihan, Elvira Ratna Aisa, Frisca Nadya Safitri, Irene Cornelia Constaty, Tukiran
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引用次数: 1

Abstract

 Syzygium samarangense is a plant that is rich in flavonoid compounds. Previous researchrevealed that the dichloromethane fraction from the stem bark extract contained fourbioactive compounds, namely, pinocembrin, uvangoletin, stercurensin, and aurentiacin,which had good antioxidant activity. However, research on the potential of these fourcompounds as an anti-inflammatory has not been revealed. This study aims to continueprevious research in revealing the potential of compounds in the dichloromethane fractionof S. samarangense extract as an anti-inflammatory agent in silico COX-2 inhibitors. Thisstudy uses in silico biocomputation, including drug-likeness analysis and molecular dockinganalysis using COX-2 protein and the control drug rofecoxib. The results showed that thereare compounds that have the potential as anti-inflammatory compounds, namelypinocembrin. However, further studies, such as in vitro and in vivo, are still needed to revealits potential as an anti-inflammatory agent
树皮二氯甲烷萃取物作为COX-2抑制剂的抗炎活性:生物信息学方法
萨马根是一种富含黄酮类化合物的植物。先前的研究发现,从茎皮提取物中提取的二氯甲烷部分含有四种生物活性化合物,分别是匹诺曹素、乌万素、stercurrensin和金合欢素,具有良好的抗氧化活性。然而,关于这四种化合物作为抗炎药的潜力的研究尚未公布。本研究旨在继续以往的研究,揭示沙棘提取物二氯甲烷部分中化合物作为抗硅COX-2抑制剂的潜力。本研究采用硅片生物计算方法,利用COX-2蛋白和对照药物罗非昔布进行药物相似性分析和分子对接分析。结果表明,有可能作为抗炎化合物的化合物,即红霉素。然而,仍需要进一步的研究,如体外和体内研究,以揭示其作为抗炎剂的潜力
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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