Natural vaginal progesterone is associated with minimal psychological side effects: a preliminary study.

S. Shantha, J. Brooks-Gunn, R. J. Locke, M. Warren
{"title":"Natural vaginal progesterone is associated with minimal psychological side effects: a preliminary study.","authors":"S. Shantha, J. Brooks-Gunn, R. J. Locke, M. Warren","doi":"10.1089/152460901317193567","DOIUrl":null,"url":null,"abstract":"The objective of this study was to evaluate the psychological side effects of a transvaginal natural progesterone gel in hormone replacement therapy (HRT). This 3-month preliminary study was part of a multicenter study previously performed in our center. We enrolled 49 women (ages 18-45 years) with hypothalamic amenorrhea (HA) (n = 40) and premature ovarian failure (POF) (n = 9). Estrogenized patients applied vaginal progesterone gel (4% or 8%) every other day for six doses per month. The Hopkins Symptom Checklist (HSCL), a psychometric profile test, was administered at baseline, day 13 of cycle 2, day 24 of cycle 2, and day 24 of cycle 3. Application of the progesterone gel caused no significant change in HSCL total scores or individual symptom scores for somatization, obsession-compulsion, interpersonal sensitivity, depression, and anxiety. Natural vaginal progesterone gel can be an effective alternative to oral progesterone for women on HRT.","PeriodicalId":80044,"journal":{"name":"Journal of women's health & gender-based medicine","volume":"58 1","pages":"991-7"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of women's health & gender-based medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/152460901317193567","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11

Abstract

The objective of this study was to evaluate the psychological side effects of a transvaginal natural progesterone gel in hormone replacement therapy (HRT). This 3-month preliminary study was part of a multicenter study previously performed in our center. We enrolled 49 women (ages 18-45 years) with hypothalamic amenorrhea (HA) (n = 40) and premature ovarian failure (POF) (n = 9). Estrogenized patients applied vaginal progesterone gel (4% or 8%) every other day for six doses per month. The Hopkins Symptom Checklist (HSCL), a psychometric profile test, was administered at baseline, day 13 of cycle 2, day 24 of cycle 2, and day 24 of cycle 3. Application of the progesterone gel caused no significant change in HSCL total scores or individual symptom scores for somatization, obsession-compulsion, interpersonal sensitivity, depression, and anxiety. Natural vaginal progesterone gel can be an effective alternative to oral progesterone for women on HRT.
天然阴道孕酮与最小的心理副作用相关:初步研究。
本研究的目的是评估经阴道天然孕酮凝胶在激素替代疗法(HRT)中的心理副作用。这项为期3个月的初步研究是本中心之前进行的一项多中心研究的一部分。我们招募了49名患有下丘脑闭经(HA) (n = 40)和卵巢早衰(POF) (n = 9)的女性(年龄18-45岁)。接受雌激素治疗的患者每隔一天使用阴道黄体酮凝胶(4%或8%),每月6次。在基线、第2周期第13天、第2周期第24天和第3周期第24天进行霍普金斯症状检查表(HSCL),这是一种心理测量量表。应用黄体酮凝胶后,HSCL总分和躯体化、强迫、人际敏感、抑郁、焦虑等单项症状评分均无显著变化。天然阴道孕酮凝胶可以有效替代口服孕酮的妇女在HRT。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信