Analysis of Water Intoxication by Drugs Using the Japanese Adverse Drug Event Report (JADER) Database

Abstract

Received June 26, 2020 Accepted November 11, 2020 Water intoxication is a group of symptoms that can lead to death. Therefore, it is important to detect the onset of water intoxication at an early stage and to respond promptly and appropriately. The Pharmaceuticals and Medical Devices Agency (PMDA) publishes information reported by the Pharmaceuticals and Medical Devices Safety Information Reporting System. In this study, to contribute to the early detection of the onset of water intoxication, we attempted to detect drugs that can induce water intoxication using PMDA’s database of Japanese Adverse Drug Event Report (JADER). We focused on reports referring to suspected drugs from JADER database of PMDA for about 15 years from April 2004 to March 2019. Adverse drug events were analyzed based on the number of reports. As a result, we detected 34 drugs that are likely to be the causative agents of water intoxication. Among these, “water intoxication” was not stated in 27 drug package inserts. It is important to pay attention to the onset of water intoxication when administering the 27 drugs we detected.