Association of lipoprotein subclasses and carotid intima-media thickness in the Chinese population

Q Medicine

Clinical Lipidology Pub Date : 2014-08-01 DOI:10.2217/clp.14.22

Fangfang Yan, L. Tian, Huangdao Yu, A. Baskota, Yun-Yi Gao, Sheyu Li, M. Fu, H. Tian

{"title":"Association of lipoprotein subclasses and carotid intima-media thickness in the Chinese population","authors":"Fangfang Yan, L. Tian, Huangdao Yu, A. Baskota, Yun-Yi Gao, Sheyu Li, M. Fu, H. Tian","doi":"10.2217/clp.14.22","DOIUrl":null,"url":null,"abstract":"Abstract Aims: To determine whether lipoprotein subclasses are associated with the carotid intima-media thickness (IMT) in Chinese population. Patients & methods: Total cholesterol (TC), triglycerides, high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were measured by standard enzymatic methods. The subclasses of LDL were determined by 1D gradient gel electrophoresis and subclasses of HDL were determined by 2D gradient gel electrophoresis in 342 participants. Carotid IMT was measured by means of high-resolution vascular ultrasound. Results: In multivariate analysis, TC and LDL-C levels were positively correlated with the carotid IMT (p < 0.001). In stepwise multiple regression analysis, small dense LDL was found to be significantly associated with IMT after adjustment for other metabolic risks and traditional lipids such as triglycerides, TC and HDL-C. Additionally, HDL subclasses were not correlated with IMT. Conclusion: Small dense LDL was a stronger predictor for carotid atherosclerosis in the general Chinese population when compared with HDL-C or HDL subclasses, which is independent of lipids and other related metabolic risks.","PeriodicalId":55252,"journal":{"name":"Clinical Lipidology","volume":"18 1","pages":"407 - 415"},"PeriodicalIF":0.0000,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Lipidology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/clp.14.22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 5

Abstract

Abstract Aims: To determine whether lipoprotein subclasses are associated with the carotid intima-media thickness (IMT) in Chinese population. Patients & methods: Total cholesterol (TC), triglycerides, high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were measured by standard enzymatic methods. The subclasses of LDL were determined by 1D gradient gel electrophoresis and subclasses of HDL were determined by 2D gradient gel electrophoresis in 342 participants. Carotid IMT was measured by means of high-resolution vascular ultrasound. Results: In multivariate analysis, TC and LDL-C levels were positively correlated with the carotid IMT (p < 0.001). In stepwise multiple regression analysis, small dense LDL was found to be significantly associated with IMT after adjustment for other metabolic risks and traditional lipids such as triglycerides, TC and HDL-C. Additionally, HDL subclasses were not correlated with IMT. Conclusion: Small dense LDL was a stronger predictor for carotid atherosclerosis in the general Chinese population when compared with HDL-C or HDL subclasses, which is independent of lipids and other related metabolic risks.

查看原文本刊更多论文

脂蛋白亚类与中国人群颈动脉内膜-中膜厚度的关系

目的:探讨脂蛋白亚类是否与中国人群颈动脉内膜-中膜厚度(IMT)相关。患者与方法:采用标准酶法测定总胆固醇(TC)、甘油三酯(triglycerides)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)。采用一维梯度凝胶电泳法测定LDL亚类，二维梯度凝胶电泳法测定HDL亚类。采用高分辨率血管超声测量颈动脉IMT。结果:在多因素分析中，TC和LDL-C水平与颈动脉IMT呈正相关(p < 0.001)。在逐步多元回归分析中，在校正其他代谢风险和甘油三酯、TC、HDL-C等传统脂质后，发现小密度LDL与IMT显著相关。此外，HDL亚类与IMT无关。结论:与HDL- c或HDL亚类相比，小密度LDL是中国普通人群颈动脉粥样硬化的一个更强的预测因子，与脂质和其他相关代谢风险无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Lipidology 生物-生化与分子生物学

CiteScore

0.44

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Clinical Lipidology is published to support the diverse array of medical professionals who work to reduce the incidence of morbidity and mortality from dyslipidemia and associated disorders of lipid metabolism. The Journal''s readership encompasses a broad cross-section of the medical community, including cardiologists, endocrinologists, and primary care physicians, as well as those involved in the treatment of such disorders as diabetes, hypertension, and obesity. The Journal also addresses allied health professionals who treat the patient base described above, such as pharmacists, nurse practitioners and dietitians. Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. While preference is given to material of immediate practical concern, the science that underpins lipidology is forwarded by expert contributors so that evidence-based approaches to reducing cardiovascular and coronary heart disease can be made immediately available to our readers. Sections of the Journal will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.