“New-Look” Opioids: Biased Ligands

J. Pergolizzi, M. Ossipov, R. Taylor, R. Raffa
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Abstract

Between the illicit use of opioids and attendant overdoses, and accidental overdoses with prescribed drugs, overuse of opioids has become a serious problem. At the same time, finding that fine balance between minimizing the risk of opioid misuse and abuse while at the same time providing access to treatment for patients who need pain control presents an ongoing challenge. Efforts to discover and develop better agents have led to what we term “new-look” opioids. We summarize here one such approach—known as biased ligands. By targeting a subset of GPCR signal transduction, this approach attempts to increase the separation between therapeutic and adverse effects.
“新面貌”阿片类药物:偏置配体
在非法使用阿片类药物及其伴随的过量和意外过量服用处方药之间,阿片类药物的过度使用已成为一个严重问题。与此同时,在尽量减少阿片类药物误用和滥用风险与同时为需要控制疼痛的患者提供治疗之间找到微妙的平衡,这是一项持续的挑战。发现和开发更好的药物的努力导致了我们所说的“新面貌”阿片类药物。我们在这里总结一种这样的方法-被称为偏置配体。通过靶向GPCR信号转导的一个子集,这种方法试图增加治疗和不良反应之间的分离。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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