Utility of cardiac biomarkers and biosensors for diagnosis of acute myocardial infarction

Abstract

Acute myocardial infarction (AMI) is the most prevalent condition that results in sickness and death worldwide. An early and accurate diagnosis of AMI is critical for prompt and appropriate treatment. Cardiac biomarkers, including myoglobin, creatinine phosphokinase (CK), and cardiac troponins, have been widely used for AMI diagnosis. More recently, new biomarkers such as heart-type fatty acid-binding protein and matrix metalloproteinases have shown promise in improving AMI diagnosis. At present, cardiac biomarkers and biosensors are used in the diagnosis and prognosis of AMI. This review article gives information on cardiac biomarkers specific to AMI and its diagnostic methods. These biomarkers have several advantages, including their high specificity for cardiac injury and their sensitivity to even small extent of cardiac damage. In addition, cardiac biomarkers can be used to assess the severity of AMI and predict the risk of complications or mortality. Recently, biosensors that can detect cardiac biomarkers in real time have been developed, allowing for an earlier and more accurate diagnosis of AMI. The utility of cardiac biomarkers and biosensors in the diagnosis of AMI underscores the importance of early and accurate diagnosis and treatment of this life-threatening condition.