Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases

Adou Adjoumanvoule Honore, Siransy Kouabla Liliane, Memel Lasme Roselle Charline, Yeboah Oppong Richard, Goran-Kouacou Amah Patricia, Kone Djakaridja, Kadiane-Oussou N'dri Juliette, Assi Aya Ursule Aniela, Gnemagnon Mahi Eric Constant, Ouattara Awa, Oura Brou Doris, Moussa Sali, Koya Hebert Gautier, Seri Yida Jocelyne, Aba Yapo Thomas, Kra Ouffoue
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Abstract

: Introduction: Blood types are most often incriminated in susceptibility to COVID-19. Blood group O subjects are reportedly less susceptible to COVID-19. However, these reports are mainly from countries with high infection rates. The overall objective of this study was to investigate the association between the risk of COVID-19 infection, its severity, and ABO-RHD blood groups at the Training Hospitals of Bouake and Cocody (Ivory Coast). Material and methods: This was a prospective study that lasted four months. All patients with COVID-19 at the time of the study and followed at the Training Hospitals of Bouake and Cocody, hospitalized in the COVID-19 centers or in home confinement, were included. T lymphocyte subpopulations were counted on the BD FACS Calibur flow cytometer after labeling. ABO and RHD blood typing was performed in all patients. Results: Of the 76 patients collected, 78.9% were homebound, 18.4% in hospital and 2.6% in the ICU. The mean age was 41.92 ± 15.13 years with a male predominance. The majority of hospitalized patients were significantly of blood group A (p=0.020). CD4 and CD8 T lymphopenia were significantly more frequent in patients with blood group A than in those with blood groups B, AB and O. Conclusion: The impact of blood group on the severity of the disease would exist. Our study showed that blood group A subjects were more likely to have COVID-19. In addition, a statistically significant association between blood type A and CD4 and CD8 T lymphopenia was found. These results should be confirmed by studies based on larger patient samples.
ABO-RHD血型与76例COVID-19相关性的初步研究
血型通常与COVID-19的易感性有关。据报道,O型血的人对COVID-19的易感性较低。然而,这些报告主要来自高感染率的国家。本研究的总体目标是调查布瓦克和科科迪培训医院(科特迪瓦)COVID-19感染风险及其严重程度与ABO-RHD血型之间的关系。材料与方法:这是一项为期四个月的前瞻性研究。所有在研究期间以及在布瓦克和科科迪培训医院随访、在COVID-19中心住院或在家隔离的COVID-19患者均被纳入研究。标记后用流式细胞仪计数T淋巴细胞亚群。所有患者均进行ABO和RHD血型分型。结果:76例患者中78.9%在家,18.4%住院,2.6%在ICU。平均年龄41.92±15.13岁,男性居多。多数住院患者为A型血(p=0.020)。A血型患者CD4和CD8 T淋巴细胞减少的发生率明显高于B、AB和o血型患者。结论:血型对疾病严重程度存在影响。我们的研究表明,A血型的受试者更容易感染COVID-19。此外,a型血与CD4和CD8 T淋巴细胞减少症之间有统计学意义的关联。这些结果应该通过基于更大患者样本的研究来证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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