Adou Adjoumanvoule Honore, Siransy Kouabla Liliane, Memel Lasme Roselle Charline, Yeboah Oppong Richard, Goran-Kouacou Amah Patricia, Kone Djakaridja, Kadiane-Oussou N'dri Juliette, Assi Aya Ursule Aniela, Gnemagnon Mahi Eric Constant, Ouattara Awa, Oura Brou Doris, Moussa Sali, Koya Hebert Gautier, Seri Yida Jocelyne, Aba Yapo Thomas, Kra Ouffoue
{"title":"Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases","authors":"Adou Adjoumanvoule Honore, Siransy Kouabla Liliane, Memel Lasme Roselle Charline, Yeboah Oppong Richard, Goran-Kouacou Amah Patricia, Kone Djakaridja, Kadiane-Oussou N'dri Juliette, Assi Aya Ursule Aniela, Gnemagnon Mahi Eric Constant, Ouattara Awa, Oura Brou Doris, Moussa Sali, Koya Hebert Gautier, Seri Yida Jocelyne, Aba Yapo Thomas, Kra Ouffoue","doi":"10.11648/j.iji.20231101.11","DOIUrl":null,"url":null,"abstract":": Introduction: Blood types are most often incriminated in susceptibility to COVID-19. Blood group O subjects are reportedly less susceptible to COVID-19. However, these reports are mainly from countries with high infection rates. The overall objective of this study was to investigate the association between the risk of COVID-19 infection, its severity, and ABO-RHD blood groups at the Training Hospitals of Bouake and Cocody (Ivory Coast). Material and methods: This was a prospective study that lasted four months. All patients with COVID-19 at the time of the study and followed at the Training Hospitals of Bouake and Cocody, hospitalized in the COVID-19 centers or in home confinement, were included. T lymphocyte subpopulations were counted on the BD FACS Calibur flow cytometer after labeling. ABO and RHD blood typing was performed in all patients. Results: Of the 76 patients collected, 78.9% were homebound, 18.4% in hospital and 2.6% in the ICU. The mean age was 41.92 ± 15.13 years with a male predominance. The majority of hospitalized patients were significantly of blood group A (p=0.020). CD4 and CD8 T lymphopenia were significantly more frequent in patients with blood group A than in those with blood groups B, AB and O. Conclusion: The impact of blood group on the severity of the disease would exist. Our study showed that blood group A subjects were more likely to have COVID-19. In addition, a statistically significant association between blood type A and CD4 and CD8 T lymphopenia was found. These results should be confirmed by studies based on larger patient samples.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"102 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of immunology and immunotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11648/j.iji.20231101.11","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
: Introduction: Blood types are most often incriminated in susceptibility to COVID-19. Blood group O subjects are reportedly less susceptible to COVID-19. However, these reports are mainly from countries with high infection rates. The overall objective of this study was to investigate the association between the risk of COVID-19 infection, its severity, and ABO-RHD blood groups at the Training Hospitals of Bouake and Cocody (Ivory Coast). Material and methods: This was a prospective study that lasted four months. All patients with COVID-19 at the time of the study and followed at the Training Hospitals of Bouake and Cocody, hospitalized in the COVID-19 centers or in home confinement, were included. T lymphocyte subpopulations were counted on the BD FACS Calibur flow cytometer after labeling. ABO and RHD blood typing was performed in all patients. Results: Of the 76 patients collected, 78.9% were homebound, 18.4% in hospital and 2.6% in the ICU. The mean age was 41.92 ± 15.13 years with a male predominance. The majority of hospitalized patients were significantly of blood group A (p=0.020). CD4 and CD8 T lymphopenia were significantly more frequent in patients with blood group A than in those with blood groups B, AB and O. Conclusion: The impact of blood group on the severity of the disease would exist. Our study showed that blood group A subjects were more likely to have COVID-19. In addition, a statistically significant association between blood type A and CD4 and CD8 T lymphopenia was found. These results should be confirmed by studies based on larger patient samples.