Effect of Dexmedetomidine Hydrochloride on Early Cognitive Function in Postoperative Elderly Patients

Wei Zhao, Chong Gao, Lijuan Cui, Fengqun Wang
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Abstract

Purpose: to explore the effect of dexmedetomidine hydrochloride on early cognitive function in postoperative elderly patients. Methods: during December 2015 to November 2016, 80 elderly patients who received surgical treatment in our hospital were selected as research object. Result: patients were randomly divided into two groups (control group and research group). On the basis of routine anesthetic induction, patients in research group took dexmedetomidine, in comparison, patients in control group took an equal dose of sodium chloride solution. The goal was to evaluate the anesthetic effect of those two methods. One hour before surgery, there was no significant difference in the MMSE score between the two groups (P>0.05). In research group, the MMSE scores at postoperative 1d and 3d were (23.8 ± 2.4) and (27.1 ± 2.0) respectively. In control group, the MMSE scores at postoperative 1d and 3d were (20.5 ± 3.2) and (24.6 ± 3.4) respectively. The difference was statistically significant (P<0.05). There was no significant difference in anesthesia time, awake time and extubation time between those two groups (P>0.05). Conclusion: using dexmedetomidine in elderly patients after surgery can protect early cognitive function and improve the prognosis.
盐酸右美托咪定对老年术后患者早期认知功能的影响
目的:探讨盐酸右美托咪定对老年术后患者早期认知功能的影响。方法:选取2015年12月至2016年11月在我院接受手术治疗的老年患者80例作为研究对象。结果:患者随机分为两组(对照组和研究组)。实验组患者在常规麻醉诱导的基础上给予右美托咪定,对照组患者给予等剂量的氯化钠溶液。目的是评价这两种方法的麻醉效果。术前1 h,两组患者MMSE评分比较,差异无统计学意义(P < 0.05)。研究组术后1d和3d MMSE评分分别为(23.8±2.4)分和(27.1±2.0)分。对照组术后1d和3d MMSE评分分别为(20.5±3.2)分和(24.6±3.4)分。差异有统计学意义(P<0.05)。两组患者麻醉时间、清醒时间、拔管时间比较,差异均无统计学意义(P < 0.05)。结论:老年患者术后应用右美托咪定可保护早期认知功能,改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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