Vaginal microbiome in patients with menstrual cycle disorders (review)

П. Лебедева, М. В. Грязнова, О. Н. Козаренко, Михаил Ю. Сыромятников, Владимир Никитович Попов
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引用次数: 6

Abstract

Background: In the last two decades, because of the usage of non-cultural methods, new data on the female genital tract microbiome have been accumulated. However, the causes determining the predominance of certain microorganisms, and, consequently, the formation of microbiome composition, have not been finally determined. The major changes in the microbiome of the reproductive tract of women occur in response to the influence of hormones. The aim of the study: To assess the influence of menstrual cycle disorders on the vaginal microbiome composition. Materials and methods: The articles describing the role of menstrual cycle disorders in the formation of the vaginal microbiome composition, published over the past 20 years and deposited in the Pubmed, Google Academy, Scopus, Elibrary, ResearchGate, and EBSCO databases, were analyzed. Results: The data on the role of the human microbiome in the pathogenesis of somatic diseases are presented. The main characteristics of the vaginal microbiome are given, its classification is presented, the main functions of Lactobacillus in the female reproductive tract and their influence on local immunity are discussed. The vaginal microbiome during the normal menstrual cycle and in patients with menstrual cycle disorders is described. Conclusion: Despite the critical importance of the female genital tract microbiome for human reproduction, data on the role of menstrual cycle disorders in the formation of the microbiome are sporadic and are mainly concerned with the vaginal microbiome in polycystic ovary syndrome (PCOS). There are no data on the role of hyperprolactinemia, congenital adrenal hyperplasia, and other causes of menstrual cycle disorders in vaginal microbiome formation. Further studies of the microbiome in patients with menstrual cycle disorders, as well as its correction, are needed.
月经周期紊乱患者阴道微生物组(综述)
背景:近二十年来,由于非培养方法的使用,积累了关于女性生殖道微生物组的新数据。然而,决定某些微生物占优势的原因,以及微生物组组成的形成,尚未最终确定。妇女生殖道微生物组的主要变化是由于激素的影响而发生的。本研究的目的:评估月经周期紊乱对阴道微生物组成的影响。材料与方法:对近20年来发表在Pubmed、谷歌Academy、Scopus、library、ResearchGate和EBSCO数据库中描述月经周期紊乱在阴道微生物组组成形成中的作用的文章进行分析。结果:介绍了人体微生物组在躯体疾病发病机制中的作用。介绍了阴道微生物群的主要特征,分类,探讨了乳酸菌在女性生殖道中的主要作用及其对局部免疫的影响。阴道微生物组在正常月经周期和月经周期紊乱的患者被描述。结论:尽管女性生殖道微生物组对人类生殖至关重要,但关于月经周期紊乱在微生物组形成中的作用的数据是零星的,主要与多囊卵巢综合征(PCOS)阴道微生物组有关。目前还没有关于高催乳素血症、先天性肾上腺增生和其他引起月经周期紊乱的原因在阴道微生物群形成中的作用的数据。需要对月经周期紊乱患者的微生物组进行进一步的研究,以及对其进行纠正。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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