Histological alteration of the pulmonary alveoli, renal cortex and spleen following exposure to open refuse dump site

MOnyije Felix, EWaritimi Gilbert, AAtoni Dogood, OIjomone Meashack, UNwoha Polycarp
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引用次数: 2

Abstract

Background: Wastes are mainly unwanted products from domestic and industrial sources, which increases due to accelerated industrialization, urbanization, and population growth. Open refuse dumping is the predominant form of waste disposal method in Nigeria and presents huge environmental and health challenges. Hence, this study investigated the effects of long-term exposure of rats to refuse dump sites on histological and serum analysis in three organs; kidney, lungs, and spleen. Materials and Methods: Twelve Wistar rats of both sexes were divided into two groups made up of 6 rats in each group. Group A was the controls and group B was the experimental. The experimental rats were exposed to refuse dump fume by keeping them in a research hut built in a refuse dump site for 8 months while the control rats were keep in the Department of Human Anatomy, Niger Delta University, Wilberforce Island, Bayelsa State. Results: There was loss of the elastic tissue support for bronchioles, alveolar wall and coalescence of adjacent alveoli as compared with the control. Serum urea concentrations were significantly increased (P < 0.05) in exposed rats (9.08 ± 1.58) compared with control rats (5.00 ± 0.32). Similarly, serum creatinine concentrations were significantly increased (P < 0.05) in exposed rats (106.20 ± 14.94) compared to Control rats (53.67 ± 5.68). All measured serum electrolytes were significantly altered (P < 0.05). Sodium ions (Na+) (90.17 ± 7.68) and bicarbonate ions (HCO3−) (2.33 ± 0.33) were significantly reduced (P < 0.05) while potassium ions (K+) (61.83 ± 6.70) and chloride ions (Cl−) (117.2 ± 3.08) were significantly increased (P < 0.05). Conclusion: Our results revealed histological distortion in experimental animals due to exposure to refuse dump site.
暴露于露天垃圾场后肺泡、肾皮质和脾脏的组织学改变
背景:废物主要是来自家庭和工业来源的不需要的产品,由于工业化、城市化和人口增长的加速而增加。露天垃圾倾倒是尼日利亚主要的废物处理方式,对环境和健康构成巨大挑战。因此,本研究探讨了长期暴露于垃圾场的大鼠对三个器官的组织学和血清分析的影响;肾,肺,脾。材料与方法:取12只雄性Wistar大鼠分为两组,每组6只。A组为对照组,B组为实验组。将实验大鼠置于垃圾场内搭建的研究棚内8个月,对照组大鼠置于巴耶尔萨州威尔伯福斯岛尼日尔三角洲大学人体解剖学系。结果:与对照组相比,细支气管、肺泡壁和相邻肺泡的弹性组织支持丧失。暴露大鼠血清尿素浓度(9.08±1.58)较对照组(5.00±0.32)显著升高(P < 0.05)。暴露组大鼠血清肌酐浓度(106.20±14.94)显著高于对照组(53.67±5.68),差异有统计学意义(P < 0.05)。血清电解质测定值均显著改变(P < 0.05)。钠离子(Na+)(90.17±7.68)和碳酸氢盐离子(HCO3−)(2.33±0.33)显著降低(P < 0.05),钾离子(K+)(61.83±6.70)和氯离子(Cl−)(117.2±3.08)显著升高(P < 0.05)。结论:我们的研究结果揭示了垃圾场暴露对实验动物的组织学扭曲。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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