Pitavastatin in the Management of Hypercholesterolemia

S. Nomura
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引用次数: 4

Abstract

Pitavastatin is an HMG-CoA reductase inhibitor that significantly reduces the plasma levels of total cholesterol, LDL-C and triglycerides, while also causing modest elevation of the plasma high-density cholesterol (HDL-C) level. This statin is minimally metabolized by the cytochrome P-450 (CYP) isozymes; it is glucuronized and converted to the inactive lactone form, which is also minimally metabolized by human hepatic microsomes; therefore, it is associated with a low frequency of drug interactions. Pitavastatin has also been shown to have various pleiotropic effects on platelets, monocytes/macrophages and endothelial cells. In addition, a new effect of pitavastatin of increasing the serum for adiponectin level has been reported recently. Pitavastatin has been reported to be associated with a lower frequency of adverse drug effects such as hepatic dysfunction and rhabdomyolysis, therefore, it may be judged as one of the safer among the strong statins. Several clinical trials of pitavastatin have been conducted. At present, its evaluation in actual clinical use by clinicians around the world is underway. Pitavastatin is an effective and safe drug for patients with hypercholesterolemia.
匹伐他汀治疗高胆固醇血症
匹伐他汀是一种HMG-CoA还原酶抑制剂,可显著降低血浆总胆固醇、LDL-C和甘油三酯水平,同时也可引起血浆高密度胆固醇(HDL-C)水平的适度升高。这种他汀类药物被细胞色素P-450 (CYP)同工酶代谢最少;它被葡萄糖醛酸化并转化为无活性的内酯形式,也被人肝微粒体最低限度地代谢;因此,它与药物相互作用的频率较低有关。匹伐他汀也被证明对血小板、单核/巨噬细胞和内皮细胞有多种多效性作用。此外,最近有报道称匹伐他汀有提高血清脂联素水平的新作用。据报道,匹伐他汀与肝功能障碍和横纹肌溶解等不良反应的发生率较低,因此,它可以被认为是强效他汀类药物中较安全的药物之一。已经进行了几次匹伐他汀的临床试验。目前,世界各地的临床医生正在对其进行临床实际应用评估。匹伐他汀对高胆固醇血症患者是一种安全有效的药物。
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